C3 Antikörper (HRP)

Produktnummer ABIN113306

Der Schaf Polyklonal Anti-C3-Antikörper wurde für WB und EIA validiert. Er ist geeignet, C3 in Proben von Human zu detektieren.

Kurzübersicht für C3 Antikörper (HRP) (ABIN113306)

Target: C3 (Complement Component 3 (C3))

Reaktivität: Human

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser C3 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-C3 Antikörper (HRP)

Spezifität: This antibody detects Complement 3c, a polypeptide fragment which is present in C3.

Aufreinigung: Affinity chromatography on Protein G.

Immunogen: Complement 3c.

Anwendungsinformationen

Applikationshinweise: Suitable for ELISA (1/200-1/800) and Western blotting (1/500-1/2000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2, containing 0.01 % Thiomersal as preservative.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized product at 2 - 8 °C. Following reconstitution store at -20 °C.

Details zu C3

Target: C3 (Complement Component 3 (C3))

Andere Bezeichnung: Complement C3

Hintergrund: C3 plays a central role in the activation of the complement system. Processing of C3 by C3 convertase is the central reaction in both classical and alternative complement pathways, resulting in C3a and C3b. C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates, and help to initiate the complement cascade, potentially resulting in cellular apoptosis. C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c and C3dg. Defects in C3 can result in susceptibility to pyogenic infection.Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CPAMD1, Complement component 3

Gen-ID: 718

NCBI Accession: NP_000055

UniProt: P01024

Pathways: Komplementsystem, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling