Inhibin alpha Antikörper (N-Term)

Produktnummer ABIN112650

Dieses Anti-Inhibin alpha-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Inhibin alpha in IHC (p), IHC (fro) und EIA. Geeignet für Human.

Kurzübersicht für Inhibin alpha Antikörper (N-Term) (ABIN112650)

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Inhibin alpha Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Produktdetails anti-Inhibin alpha Antikörper

Bindungsspezifität: AA 1-24, N-Term

Sequenz: S-T-P-L-M-S-W-P-W-S-P-S-A-L-R-L-L-Q-R-P-P-E-E-P-G-Y

Spezifität: This antibody recognizes Inhibin alpha, which is expressed in a range of tissues including prostate, brain, adrenal gland, testis and ovary.

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: Synthetic peptide corresponding to the amino acids 1-24 of Human Inhibin alpha

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections: 1/400. This antibody stains primordial follicles when using paraffin embedded, formalin fixedfragments of human ovarian cortex.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 5.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Inhibin alpha

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Andere Bezeichnung: Inhibin alpha / INHA

Hintergrund: Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibins are also involved in regulating diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins, as inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibin has 2 subunits (alpha and beta) that are coded by separate genes. The alpha subunit determines whether inhibin or activin will be produced. The alpha subunit remains constant, such that the various types of inhibin are defined by the beta subunit (a,b,c,d). Inhibin A is a dimer of alpha and beta A. Inhibin B is a dimer of alpha and beta B. Proteolytic processing yields a number of inhibin alpha bioactive forms: the 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N terminal propeptide linked through a disulfide bond to the mature alpha chain, and the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono or diglycosylated, causing the mass difference.

Gen-ID: 3623

NCBI Accession: NP_002182

UniProt: P05111

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion