beta Endorphin Antikörper

Produktnummer ABIN111318

Produktdetails anti-beta Endorphin Antikörper

Target: beta Endorphin (beta-EP) (Endorphin beta (beta-EP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Endorphin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Protein A affinity chromatography

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Human beta-endorphin (full length native protein)

Klon: B31-15

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (paraffin sections): 10 - 20 mg/mL. Staining technique: Standard ABC technique (DAB+). Pretreatment: Heat retrieval (microwave oven). Incubation: overnight at 4 C. Positive tissue: Human pituitary gland. Immunohistochemistry (frozen sections).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH ~7.4, 15 mM Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing. Dilute only prior to immediate use

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-beta Endorphin Antikörper (ABIN111318)

Millenbaugh, Baskin, DeSilva, Elliott, Glickman: "Photothermal killing of Staphylococcus aureus using antibody-targeted gold nanoparticles." in: International journal of nanomedicine, Vol. 10, pp. 1953-60, (2016) (PubMed).

Fröbel, Cadeddu, Hartwig, Bruns, Wilk, Kündgen, Fischer, Schroeder, Steidl, Germing, Lehr, Haas, Czibere: "Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes." in: Molecular & cellular proteomics : MCP, Vol. 12, Issue 5, pp. 1272-80, (2013) (PubMed).

Meier, Köhler, Alkhatib, Sergi, Junker, Klein, Schmidt, Fritsch: "Beta-cell development and turnover during prenatal life in humans." in: European journal of endocrinology, Vol. 162, Issue 3, pp. 559-68, (2010) (PubMed).

Ubuka, Lai, Kitani, Suzuuchi, Pham, Cadigan, Wang, Chowdhury, Tsutsui, Bentley: "Gonadotropin-inhibitory hormone identification, cDNA cloning, and distribution in rhesus macaque brain." in: The Journal of comparative neurology, Vol. 517, Issue 6, pp. 841-55, (2009) (PubMed).

Stenholm, Hakanen, Vaarno, Pihlasalo, Terho, Hänninen, Vuopio-Varkila, Huovinen, Kotilainen: "Methicillin-resistant Staphylococcus aureus screening by online immunometric monitoring of bacterial growth under selective pressure." in: Antimicrobial agents and chemotherapy, Vol. 53, Issue 12, pp. 5088-94, (2009) (PubMed).

Hilgert, Stolba, Kristofová, Stefanová, Bendlová, Lebl, Horejsí: "A monoclonal antibody applicable for determination of C-peptide of human proinsulin by RIA." in: Hybridoma, Vol. 10, Issue 3, pp. 379-86, (1991) (PubMed).

Details zu beta Endorphin

Target: beta Endorphin (beta-EP) (Endorphin beta (beta-EP))

Andere Bezeichnung: beta Endorphin (beta-EP Produkte)

Synonyme: ACTH antikoerper, BE antikoerper, Beta-LPH antikoerper, Clip antikoerper, Gamma-LPH antikoerper, Npp antikoerper, Pomc-1 antikoerper, Pomc1 antikoerper, alpha-MSH antikoerper, alphaMSH antikoerper, beta-MSH antikoerper, gamma-MSH antikoerper, CLIP antikoerper, LPH antikoerper, MSH antikoerper, NPP antikoerper, POC antikoerper, pro-opiomelanocortin-alpha antikoerper, proopiomelanocortin antikoerper, Pomc antikoerper, POMC antikoerper

Hintergrund: Beta-Endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system. Beta-Endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor pro-opiomelanocortin (POMC). Beta-Endorphin is found in neurons of the hypothalamus as well as the pituitary gland. It is an agonist of the opioid receptors, with evidence suggesting that it serves as the endogenous ligand of the μ-opioid receptor, the same receptor to which the chemicals extracted from opium, such as morphine and codeine, have their analgesic and addictive effects. Beta-Endorphin occurs in cells in the anterior pituitary. Beta-Endorphin may be detected in tumors of the pituitary, gastroinestinal and bronchial carcinoids. Absorption with 10-100 μg beta-Endorphin per ml diluted antiserum inactivates the antiserum, while Beta-lipotropin, met-enkephalin and leu-enkephalin do not.Synonyms: Endorfin-beta, Endorphin-beta

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity