TUBB Antikörper (C-Term)

Produktnummer ABIN1112713

Dieses Maus Monoklonal-Antikörper erkennt spezifisch TUBB in WB und IF. Er zeigt eine Reaktivität gegenüber Maus, Ratte, Affe, Hund und Hamster.

Kurzübersicht für TUBB Antikörper (C-Term) (ABIN1112713)

Target: TUBB (Tubulin, beta (TUBB))

Reaktivität: Maus, Ratte, Affe, Hund, Hamster

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TUBB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-TUBB Antikörper

Bindungsspezifität: C-Term

Spezifität: Detect the endogenous levels of total beta-Tubulin protein.

Immunogen: Protein fragment on C-terminal of human beta-Tubulin.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot (1:5000), Immunofluorescence(1:1000) .Other applications have not been tested. The optimal dilutions should be determined by end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C for 1 year. Avoid repeated freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu TUBB

Target: TUBB (Tubulin, beta (TUBB))

Andere Bezeichnung: beta-Tubulin

Hintergrund: Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of alpha- and beta-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8. 1 Mutant huntingtin, disrupted intracellular transport and insulin secretion by direct interference with microtubular beta-tubulin. Mutant huntingtin impaired glucose-stimulated insulin secretion in insulin-producing beta cells, without altering stored levels of insulin. Smith et al. (2009) proposed a novel pathogenetic process by which mutant huntingtin may disrupt hormone exocytosis from beta cells and possibly impair vesicular transport in any cell that expresses the pathogenic protein. 2

Pathways: Microtubule Dynamics, M Phase