Cardiotrophin 1 Antikörper

Produktnummer ABIN1110877

Produktdetails anti-Cardiotrophin 1 Antikörper

Target: Cardiotrophin 1 (CTF1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cardiotrophin 1 Antikörper ist unkonjugiert

Applikation: ELISA

Verwendungszweck: Mouse Anti-Human CT1

Produktmerkmale: Cardiac Markers

Aufreinigung: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with the immunogen.PurificationThe IgG fraction of tissue culture supernatant was purified by Protein A/G affinity chromatography.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: The antibody is supplied as lyophilized and purified antibody originally containing PBS without any preservatives. Protein amount is indicated on the vial. Reconstitute in de-ionized or distilled water to concentration of 1 mg/mL.

Buffer: PBS

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: -20°C

Referenzen für anti-Cardiotrophin 1 Antikörper (ABIN1110877)

Li, Ma, Wang, Zeng, Li, Kang, Hao: "Exosomal microRNA-141 is upregulated in the serum of prostate cancer patients." in: OncoTargets and therapy, Vol. 9, pp. 139-48, (2016) (PubMed).

Details zu Cardiotrophin 1

Target: Cardiotrophin 1 (CTF1)

Andere Bezeichnung: CT1 (CTF1 Produkte)

Hintergrund:

Target Description: Cardiotrophin-1 (CT-1, Official gene name: CTF1) is a cardiac hypertrophic factor and belongs to the IL-6 cytokine family. The protein interacts with the glycoprotein 130/leukemia inhibitory factor receptor beta heterodimer. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice. In addition, CT-1 enhances transcription factor NF kappa B DNA-binding activities and activates phosphatidylinositol 3-kinase in cardiac myocytes. It is also highly expressed in the heart, prostate, skeletal muscle, and ovary, and expressed at the lower levels in lung, kidney, pancreas, thymus, small intestine, and testis. CT-1 is highly secreted by myotubes, and promotes the survival of cultured embryonic mouse and rat MNs. CT-1 is associated with pathophysiology of heart diseases, like hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.

Pathways: JAK-STAT Signalweg