PLAU Antikörper

Produktnummer ABIN1109451

Dieses Anti-PLAU-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von PLAU in WB, EIA, IHC (fro), RIA und DB. Geeignet für Human.

Kurzübersicht für PLAU Antikörper (ABIN1109451)

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PLAU Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Radioimmunoassay (RIA), Dot Blot (DB)

Klon: PGM2005

Produktdetails anti-PLAU Antikörper

Spezifität: The antibody binds to Human High Molecular Weight single-chain Urokinase type plasminogen activator (HMW-scuPA, 54 kDa), to High Molecular Weight two-chain Urokinase type plasminogen activator (HMW-tcuPA, 52 kDa) and to Low Molecular Weight single-chain Urokinase type plasminogen activator (LMW-scuPA, 33 kDa) with high affinity (Kd= 0.1 nM) and does not inhibit the ability of urokinase to activate plasminogen. Urokinase reaction with synthetic substrate S2444 is not inhibited. The antibody is highly specific for urokinase, no crossreactions were found with other serine proteases (tissue plasminogen activator, plasmin, trypsin, chymotrypsin, elastase, thrombin). Human whole plasma or plasma proteins do not interfere with its binding to Urokinase. Crossreacts with Rat scu/tcu PA.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: PEG6000 Precipitation and DEAE Cellulose Chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Restore with 1 mL distilled water and add preservative if preferred.

Konzentration: 0.2 mg/mL

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu PLAU

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Andere Bezeichnung: uPA / PLAU

Hintergrund: This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]Synonyms: U-plasminogen activator, Urokinase, Urokinase-type plasminogen activator, Urokinase-type plasminogen activator chain B, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A

Gen-ID: 5328

NCBI Accession: NP_001138503

UniProt: P00749

Pathways: Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagie, Smooth Muscle Cell Migration