Transglutaminase 2 Antikörper

Produktnummer ABIN1109303

Es gibt 1 Publikation für dieses Produkt. Der Maus Monoklonal anti-Transglutaminase 2 Antikörper wird verwendet zum Nachweis von Transglutaminase 2 in Proben von Human und Meerschweinchen. Er wurde validiert für WB, IHC (fro) und EIA.

Kurzübersicht für Transglutaminase 2 Antikörper (ABIN1109303)

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Reaktivität: Human, Meerschweinchen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Transglutaminase 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: 7D2

Produktdetails anti-Transglutaminase 2 Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Human, Guinea Pig.

Aufreinigung: Affinity Chromatography on Protein A

Isotyp: IgG3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in distilled water.

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None

Referenzen für anti-Transglutaminase 2 Antikörper (ABIN1109303)

Maffei, Laverrière, Wu, Triboulet, Perrinet, Duchateau, Matondo, Hollis, Gourley, Rupp, Keillor, Subtil: "Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells." in: The EMBO journal, Vol. 39, Issue 8, pp. e102166, (2020) (PubMed).

Details zu Transglutaminase 2

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Andere Bezeichnung: Transglutaminase-2

Hintergrund: Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase. Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions. It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling