PTK7 Antikörper (N-Term)

Produktnummer ABIN1108790

Der Kaninchen Polyklonal anti-PTK7 Antikörper wird verwendet zum Nachweis von PTK7 in Proben von Human, Maus und Huhn. Er wurde validiert für WB, EIA und IHC (fro).

Kurzübersicht für PTK7 Antikörper (N-Term) (ABIN1108790)

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Reaktivität: Human, Maus, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTK7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-PTK7 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts specifically with Human 112 kDa CCK-4.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Chicken.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from Human N-terminal region of CCK-4

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in distilled water.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer

Details zu PTK7

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Andere Bezeichnung: PTK7 / CCK4

Hintergrund: PTK7 is a member of the receptor tyrosine kinase family otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle. PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates. Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.Synonyms: CCK-4, Colon carcinoma kinase 4, Tyrosine-protein kinase-like 7

Gen-ID: 5754

NCBI Accession: NP_002812

Pathways: RTK Signalweg, Tube Formation