NEDD8 Antikörper
Kurzübersicht für NEDD8 Antikörper (ABIN1108403)
Target
Alle NEDD8 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Spezifität
- This antibody reacts to NEDD8.
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Kreuzreaktivität (Details)
- Species reactivity (tested):Human.
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Aufreinigung
- Purified
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Isotyp
- IgG1
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1.0 mg/mL
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Buffer
- PBS, 0.05 % sodium azide, 0,5 % BSA
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- NEDD8 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8))
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Andere Bezeichnung
- NEDD8
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Hintergrund
- Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.Synonyms: Neural precursor cell expressed developmentally down-regulated protein 8
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Molekulargewicht
- 9 kDa
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Gen-ID
- 4738
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Pathways
- Ubiquitin Proteasome Pathway
Target
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