NEDD8 Antikörper

Produktnummer ABIN1108403

Der Maus-Monoklonal Anti-NEDD8-Antikörper wurde für WB, IF, IHC (p), FACS und EIA validiert. Er ist geeignet zum Nachweis von NEDD8 in Proben aus Human. }

Kurzübersicht für NEDD8 Antikörper (ABIN1108403)

Target: NEDD8 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NEDD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Klon: 1A7

Produktdetails anti-NEDD8 Antikörper

Spezifität: This antibody reacts to NEDD8.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Purified

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS, 0.05 % sodium azide, 0,5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu NEDD8

Target: NEDD8 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8))

Andere Bezeichnung: NEDD8

Hintergrund: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.Synonyms: Neural precursor cell expressed developmentally down-regulated protein 8

Molekulargewicht: 9 kDa

Gen-ID: 4738

Pathways: Ubiquitin Proteasome Pathway