Mbl1 Antikörper

Produktnummer ABIN1108168

Dieser Ratte Monoklonal Antikörper detektiert spezifisch Mbl1 in WB, IF, EIA und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für Mbl1 Antikörper (ABIN1108168)

Target: Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Mbl1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 8G6

Produktdetails anti-Mbl1 Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Mouse

Aufreinigung: Protein G

Immunogen: Purified mouse MBL-A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu Mbl1

Target: Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))

Andere Bezeichnung: MBL-A

Hintergrund: Mannose Binding Lectin (MBL), also called mannosebinding protein (MBP), is a calcium dependent oligomeric protein that belongs to the collectin family of proteins. It contains a collagen-like domain and a carbohydrate recognition domain enabling MBL to recognize carbohydrates (such as mannose and N-acetylglucosamine) on pathogens. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways, by using attached mannose binding lectin-associated serine proteases (MASP-2) in an antibody- and C1q-independent manner. MASP-2 permits cleavage of C4 and C2 to form a C3 convertase. Once it has bound, MBL exhibits complement-dependent antibacterial activities such as microbial opsonization and/or microbial lysis via membrane attack complexes and therefore plays an important role in innate immunity. In human, MBL is encoded by a single gene, whereas in mice there are two homologous proteins, termed MBL-A and MBL-C. The MBL-A concentration in serum is about 6-fold lower compared to that of MBL-C... MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. Moreover, it has been shown that MBL-A deficient mice have aberrant antigen-specific IgM responses and suffer from increased susceptibility to infection.

Gen-ID: 17194

NCBI Accession: NP_034905

UniProt: P39039