Mbl1 Antikörper

Produktnummer ABIN1108168

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch Mbl1 in WB, IF, EIA und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für Mbl1 Antikörper (ABIN1108168)

Target: Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Mbl1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 8G6

Produktdetails anti-Mbl1 Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Mouse

Aufreinigung: Protein G

Immunogen: Purified mouse MBL-A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu Mbl1

Target: Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))

Andere Bezeichnung: MBL-A

Hintergrund: Mannose Binding Lectin (MBL), also called mannosebinding protein (MBP), is a calcium dependent oligomeric protein that belongs to the collectin family of proteins. It contains a collagen-like domain and a carbohydrate recognition domain enabling MBL to recognize carbohydrates (such as mannose and N-acetylglucosamine) on pathogens. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways, by using attached mannose binding lectin-associated serine proteases (MASP-2) in an antibody- and C1q-independent manner. MASP-2 permits cleavage of C4 and C2 to form a C3 convertase. Once it has bound, MBL exhibits complement-dependent antibacterial activities such as microbial opsonization and/or microbial lysis via membrane attack complexes and therefore plays an important role in innate immunity. In human, MBL is encoded by a single gene, whereas in mice there are two homologous proteins, termed MBL-A and MBL-C. The MBL-A concentration in serum is about 6-fold lower compared to that of MBL-C... MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. Moreover, it has been shown that MBL-A deficient mice have aberrant antigen-specific IgM responses and suffer from increased susceptibility to infection.

Gen-ID: 17194

NCBI Accession: NP_034905

UniProt: P39039