Lamin B1 Antikörper (C-Term)

Produktnummer ABIN1108013

Der Kaninchen Polyklonal Anti-Lamin B1-Antikörper wurde für WB, IP, IF, IHC (p) und IHC (fro) validiert. Er ist geeignet, Lamin B1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Lamin B1 Antikörper (C-Term) (ABIN1108013)

Target: Lamin B1 (LMNB1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Lamin B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Lamin B1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects Lamin Beta at C-term. No cross reactivity with other proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Immunogen affinity purified

Immunogen: Synthetic peptide corresponding to a sequence at the C-terminal of human Lamin B .Remarks: Sequence is different from the related rat and mouse sequence by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu Lamin B1

Target: Lamin B1 (LMNB1)

Andere Bezeichnung: Lamin-B1 (LMNB1)

Hintergrund: Lamins are the major components of the nuclear lamina which underlies the nuclear envelope of eukaryotic cells. lamin B is a structural component of the long-sought-after spindle matrix that promotes microtubule assembly and organization in mitosis. Inspection of the deduced amino acid sequence of lamin B revealed the presence in coil 1B of the alpha-helical domain of a leucine heptad repeat region.Lamin B assembled into a matrix-like network in mitosis through a process that depended on the presence of the guanosine triphosphate-bound form of the small guanosine triphosphatase Ran.Synonyms: LMN2, LMNB, Lamin B1, Lamin B1/B2, Lamin B2

Gen-ID: 4001

NCBI Accession: NP_005564

UniProt: P20700

Pathways: Apoptose, Caspase Kaskade in der Apoptose