IL-4 Antikörper (PE)

Produktnummer ABIN1107850

Dieser Maus Monoklonal Antikörper detektiert spezifisch IL-4 in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für IL-4 Antikörper (PE) (ABIN1107850)

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-4 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: 8F-12

Produktdetails anti-IL-4 Antikörper (PE)

Spezifität: The antibody detects human Interleukin 4, which is a 14 kDa molecular weight glycoprotein. Other species not tested.

Aufreinigung: Affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.

Details zu IL-4

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Andere Bezeichnung: Interleukin-4 / IL4

Hintergrund: The immune system reacts to a pathogen by activation of balanced network of the humoral and cellular immune responses. Subsequently the activated condition of the immune system will, after the elimination of the pathogen, be down-regulated to a balanced situation again. Control of the immune response requires efficient communication between the different cells involved in this response. This interaction is provided by cell/cell contact and by a complex array of mediators. Among these mediators cytokines, soluble factors produced by these cells, play an important role. Cytokines can act on other cells locally or distantly, but can be even auto regulating. Cytokines can behave stimulatory or inhibitory, or can even perform both activities, depending on the (pre)activation stage of the target cell. (3, 4) Interleukine 4 (IL-4) is a cytokine expressed by activated T cells, mast cells and bone marrow stromal cells. Originally, IL-4 was referred to as the B cell differentiation factor, B cell growth factor 1 or B cell stimulatory factor 1. The function of IL-4 is pleiotropic, i.e. stimulation, proliferation induction, and modulation of target cell functions. These target cells include B cells, but also T cells, NK and LAK cells, as well as antigen-processing cells like monocytes and macrophages.Synonyms: B-cell stimulatory factor 1, BSF1, Binetrakin, IL-4, Lymphocyte stimulatory factor 1, Pitrakinra

Gen-ID: 3565

NCBI Accession: NP_000580

UniProt: P05112

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation