IL27 Antikörper (FITC)

Produktnummer ABIN1107838

Dieses Maus Monoklonal-Antikörper erkennt spezifisch IL27 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für IL27 Antikörper (FITC) (ABIN1107838)

Target: IL27 (Interleukin-27 Subunit alpha (IL27))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL27 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Klon: B-G49

Produktdetails anti-IL27 Antikörper (FITC)

Spezifität: Recognizes both natural and recombinant Human IL-27

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Ion Exchange Chromatography.

Immunogen: Recombinant Human IL-27.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 5 % BSA as stabilizer and 0.09 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu IL27

Target: IL27 (Interleukin-27 Subunit alpha (IL27))

Andere Bezeichnung: Interleukin-27 / IL27A

Hintergrund: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.Synonyms: IL-27 subunit alpha, IL-30, IL27-A, IL30, Interleukin-30, p28

Gen-ID: 246778

NCBI Accession: NP_663634

UniProt: Q8NEV9