IL12B Antikörper

Produktnummer ABIN1107794

Der Maus Monoklonal anti-IL12B Antikörper wird verwendet zum Nachweis von IL12B in Proben von Human, Schaf und Rind (Kuh). Er wurde validiert für WB, FACS, EIA, Func und ELISpot.

Kurzübersicht für IL12B Antikörper (ABIN1107794)

Target: IL12B (Interleukin 12 beta (IL12B))

Reaktivität: Human, Schaf, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL12B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Functional Studies (Func), ELISpot

Klon: CC301

Produktdetails anti-IL12B Antikörper

Spezifität: This antibody recognises the p40 subunit of Bovine Interleukin-12, and binds to both the free subunit and the intact heterodimer.

Aufreinigung: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Endotoxin-Niveau: < 0.01 EU/μg

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, None, None

Details zu IL12B

Target: IL12B (Interleukin 12 beta (IL12B))

Andere Bezeichnung: Interleukin-12 beta / IL12B

Hintergrund: Interleukin 12 (IL12) can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine activated killer cells, and stimulate the production of IFN gamma by resting PBMC. IL12 induces IFN gamma, TNF alpha production in T and NK cells, costimulation of PBL proliferation, proliferation/differentiation of TH1 T lymphocytes. It is downregulated by IL10, homodimeric p40 antagonistic to functional p70 heterodimer. IL12R beta 1 binds p40 but when dimeric with IL12R beta 2 binds p35.Synonyms: CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL-12B, Interleukin-12B, NK cell stimulatory factor chain 2, NKSF2

Gen-ID: 281857

Pathways: JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation