HMGB1 Antikörper

Produktnummer ABIN1107584

Der Maus Monoklonal Anti-HMGB1-Antikörper wurde für WB validiert. Er ist geeignet, HMGB1 in Proben von Human, Maus, Ratte und Schwein zu detektieren.

Kurzübersicht für HMGB1 Antikörper (ABIN1107584)

Target: HMGB1 (High Mobility Group Box 1 (HMGB1))

Reaktivität: Human, Maus, Ratte, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HMGB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: KS1

Produktdetails anti-HMGB1 Antikörper

Spezifität: This antibody reacts with human, mouse, rat and porcine HMGB1.

Aufreinigung: Protein A agarose

Immunogen: Porcine HMGB1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C.

Details zu HMGB1

Target: HMGB1 (High Mobility Group Box 1 (HMGB1))

Andere Bezeichnung: HMGB1

Hintergrund: High mobility group box 1 (HMGB1), named for its rapid migration properties on electrophoretic gels, is a member of the nonhistone chromatin-associated proteins. HMGB1 is translated as a 214 amino acid protein and is extensively modified posttranslationally by glycosylation, acylation, methylation, and phosphorylation. The primary structure is evolutionarily conserved, with 100 % amino acid sequence homology between rat and mouse and 99 % homology between rodent and human. Intracellular HMGB1 has previously been studied for its roles in binding DNA, stabilizing nucleosome formation, as a general transcription factor for nucleolar and mitochondrial RNA polymerases, and as a gene- and tissue-specific transcriptional regulator that can enhance transcription and/or replication. Extracellular HMGB1 has recently been implicated as a late mediator of delayed endotoxin lethality, because murine and human macrophages/monocytes release large amounts of a 29 kDa form of HMGB1 when stimulated by exposure to bacterial endotoxin.Synonyms: Amphoterin, HMG-1, HMG1, HMGB-1, High mobility group protein 1, High mobility group protein B1

Molekulargewicht: 29 kDa

Gen-ID: 3146

NCBI Accession: NP_002119

UniProt: P09429

Pathways: p53 Signalweg, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome