HES1 Antikörper (C-Term)

Produktnummer ABIN1107521

Der Kaninchen Polyklonal Anti-HES1-Antikörper wurde für WB, IHC (fro) und EIA validiert. Er ist geeignet, HES1 in Proben von Maus zu detektieren.

Kurzübersicht für HES1 Antikörper (C-Term) (ABIN1107521)

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HES1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Produktdetails anti-HES1 Antikörper

Bindungsspezifität: C-Term

Spezifität: Reacts with Mouse 30 kDa Hes1 protein. Cross reacts with Rat and Human.

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from C-terminal domain of HES-1 protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in distilled water.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer

Details zu HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Andere Bezeichnung: HES1

Hintergrund: HES1 is a nuclear protein belonging to th basic helix-loop-helix family of transcription factors with a basic helix-loop-helix (bHLH) domain and an Orange domain. The basic domain of HES1 contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. An immediate early response gene to growth factor, HES1 is reported as having a dual function of both transcriptional activator and silencer of acid alpha-glucosidase (GAA), thus contributing to the subtle tissue-specific control of housekeeping genes such as GAA. HES1 a transcriptional repressor of genes which require a bHLH protein for their transcription and also the formation of a complex with a corepressor protein (Groucho) such as TLE2. HES1 may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.Synonyms: HES-1, HHL, HL, HRY, Hairy and enhancer of split 1, Hairy homolog, Hairy-like

Gen-ID: 15205

NCBI Accession: NP_032261

Pathways: DNA Reparatur