HES1 Antikörper

Produktnummer ABIN1107520

Dieses Maus Monoklonal-Antikörper erkennt spezifisch HES1 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für HES1 Antikörper (ABIN1107520)

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HES1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: 7C2g2

Produktdetails anti-HES1 Antikörper

Spezifität: Reacts with Human 30 kDa HES-1 protein. May cross react with Mouse and Rat.

Aufreinigung: Affinity Chromatography on Protein A

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in distilled water.

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None

Details zu HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Andere Bezeichnung: HES1

Hintergrund: HES1 is a nuclear protein belonging to th basic helix-loop-helix family of transcription factors with a basic helix-loop-helix (bHLH) domain and an Orange domain. The basic domain of HES1 contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. An immediate early response gene to growth factor, HES1 is reported as having a dual function of both transcriptional activator and silencer of acid alpha-glucosidase (GAA), thus contributing to the subtle tissue-specific control of housekeeping genes such as GAA. HES1 a transcriptional repressor of genes which require a bHLH protein for their transcription and also the formation of a complex with a corepressor protein (Groucho) such as TLE2. HES1 may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.Synonyms: HES-1, HHL, HL, HRY, Hairy and enhancer of split 1, Hairy homolog, Hairy-like

Gen-ID: 3280

Pathways: DNA Reparatur