EYA3 Antikörper (Middle Region)

Produktnummer ABIN1107155

Der Kaninchen Polyklonal Anti-EYA3-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, EYA3 in Proben von Human, Maus, Ratte und Hund zu detektieren.

Kurzübersicht für EYA3 Antikörper (Middle Region) (ABIN1107155)

Target: EYA3 (Eyes Absent Homolog 3 (EYA3))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-EYA3 Antikörper

Bindungsspezifität: Middle Region

Sequenz: QSRKNMTSKN RGKRKADATS SQDSELERVF LWDLDETIII FHSLLTGSYA

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, DogSpecies reactivity (tested):Human

Aufreinigung: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-EYA3 antibody: synthetic peptide directed towards the middle region of human EYA3.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu EYA3

Target: EYA3 (Eyes Absent Homolog 3 (EYA3))

Andere Bezeichnung: EYA3

Hintergrund: EYA3 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. This protein promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. EYA3 coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity.Synonyms: Eyes absent homolog 3

Gen-ID: 2140

NCBI Accession: NP_001981

Pathways: Positive Regulation of Response to DNA Damage Stimulus