Desmoplakin Antikörper

Produktnummer ABIN1106984

Der Kaninchen Polyklonal anti-Desmoplakin Antikörper wird verwendet zum Nachweis von Desmoplakin in Proben von Human. Er wurde validiert für WB, IHC (fro) und EIA.

Kurzübersicht für Desmoplakin Antikörper (ABIN1106984)

Target: Desmoplakin (DSP)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Desmoplakin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Produktdetails anti-Desmoplakin Antikörper

Spezifität: Reacts with Human 331 kDa Desmoplakin.

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from an internal domain of Human DP

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in distilled water.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer

Details zu Desmoplakin

Target: Desmoplakin (DSP)

Andere Bezeichnung: Desmoplakin

Hintergrund: Desmoplakin is an obligate component of functional desmosomes that attaches intermediate filaments to desmosomal plaques. It is involved in the organization of desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains. The N-terminus of desmoplakin is essential for localisation to the desmosome and interaction with plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds to intermediate filaments. The central region of desmoplakin comprises a coiled-coil rod domain that mediates homodimerisation. There are two isoforms of desmoplakin - desmoplakin I, which is an obligate component of all desmosomes, and desmoplakin II, which is predominantly expressed in tissues and cells of stratified origin. Mutations in the gene encoding desmoplakin result in a number of cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP

Gen-ID: 1832

NCBI Accession: NP_001008844

Pathways: Cell-Cell Junction Organization