COL2 Antikörper

Produktnummer ABIN1106745

Dieses Anti-COL2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von COL2 in IHC (p), IHC (fro), Func und EIA. Geeignet für Human, Maus, Ratte, Huhn und Rind (Kuh).

Kurzübersicht für COL2 Antikörper (ABIN1106745)

Target: COL2 (Collagen, Type II (COL2))

Reaktivität: Human, Maus, Ratte, Huhn, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser COL2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Enzyme Immunoassay (EIA)

Klon: CIIC1

Produktdetails anti-COL2 Antikörper

Spezifität: The monoclonal antibody CIICI reacts with the C1 epitope (triple helical position 358-364) of collagen type II. It has been shown to induce CAIA in naive mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody M2139, binding to the J1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity. The monoclonal antibody CIIC1 is cross reactive with rat, bovine, chicken and human CII.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat chicken, bovine

Aufreinigung: Protein G

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu COL2

Target: COL2 (Collagen, Type II (COL2))

Andere Bezeichnung: Collagen Type II

Hintergrund: Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA).Synonyms: COL2, Collagen II

Gen-ID: 1280

NCBI Accession: NP_001835

UniProt: P02458