COL2 Antikörper

Produktnummer ABIN1106744

Der Maus Monoklonal Anti-COL2-Antikörper wurde für IHC (p), IHC (fro), Func und EIA validiert. Er ist geeignet, COL2 in Proben von Human, Maus, Ratte, Huhn und Rind (Kuh) zu detektieren.

Kurzübersicht für COL2 Antikörper (ABIN1106744)

Target: COL2 (Collagen, Type II (COL2))

Reaktivität: Human, Maus, Ratte, Huhn, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser COL2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Enzyme Immunoassay (EIA)

Klon: M2139

Produktdetails anti-COL2 Antikörper

Spezifität: The monoclonal antibody M2139 reacts with the J1 epitope (triple helical position 551-564) of collagen type II. It has been shown to induce CAIA in naive mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody CIIC1 (cat.no. AM26375PU-N), binding to the C1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat, bovine, chicken

Aufreinigung: Protein G

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu COL2

Target: COL2 (Collagen, Type II (COL2))

Andere Bezeichnung: Collagen Type II

Hintergrund: Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA).Synonyms: COL2, Collagen II

Gen-ID: 1280

NCBI Accession: NP_001835

UniProt: P02458