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CKB Antikörper (N-Term)

CKB Reaktivität: Human, Maus, Ratte, Kaninchen WB, IF, IHC (fro), IHC (p) Wirt: Maus Monoclonal CK-BYK-21E10 unconjugated
Produktnummer ABIN1106703
  • Target Alle CKB Antikörper anzeigen
    CKB (Creatine Kinase, Brain (CKB))
    Bindungsspezifität
    • 11
    • 10
    • 8
    • 8
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 95
    • 50
    • 35
    • 12
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Kaninchen
    Wirt
    • 83
    • 29
    • 2
    Maus
    Klonalität
    • 75
    • 38
    Monoklonal
    Konjugat
    • 55
    • 21
    • 10
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser CKB Antikörper ist unkonjugiert
    Applikation
    • 75
    • 48
    • 27
    • 17
    • 16
    • 10
    • 10
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Sequenz
    SNSHNALKLR FPAEDEF
    Spezifität
    The monoclonal antibody CK-BYK/21E10 recognizes creatine kinase B-type, also known as CKB.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat, rabbit
    Aufreinigung
    Protein G
    Immunogen
    Synthetic 17-mer peptide corresponding to the N-terminal sequence of human creatine kinase brain-type
    Klon
    CK-BYK-21E10
    Isotyp
    IgG2b
    Top Product
    Discover our top product CKB Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C.
  • Target
    CKB (Creatine Kinase, Brain (CKB))
    Andere Bezeichnung
    CKBB (CKB Produkte)
    Synonyme
    B-CK antikoerper, CKBB antikoerper, b-ck antikoerper, ckbb antikoerper, CKB antikoerper, Bck antikoerper, Ck-3 antikoerper, Ck3 antikoerper, Ckbb antikoerper, bck antikoerper, ckb antikoerper, cb594 antikoerper, wu:fj36f10 antikoerper, wu:fj37d11 antikoerper, Ckbr antikoerper, mg:cb02h12 antikoerper, wu:fb62d04 antikoerper, wu:fc14g11 antikoerper, zgc:154095 antikoerper, zgc:92079 antikoerper, creatine kinase B antikoerper, creatine kinase, brain L homeolog antikoerper, creatine kinase B-type antikoerper, creatine kinase, brain antikoerper, creatine kinase, brain b antikoerper, creatine kinase, brain a antikoerper, CKB antikoerper, ckb.L antikoerper, Ckb antikoerper, ckb antikoerper, ckbb antikoerper, ckba antikoerper
    Hintergrund
    Human CKB is a protein of 381 amino acids (~45 kDa), expressed in a number of tissues. CKB is most abundant in adult brain, approx. 5-fold lower in the stomach, 10-fold lower in the heart and barely detectable in liver. In brain, whereas most CKB has been shown to be cytosolic, several of the reactions requiring CKB are membrane-associated. CKB belongs to the creatine kinase (CK) isoenzymes that catalyse the synthesis of phosphocreatine (PCr) and its subsequent use in the regeneration of ATP in cell types where the consumption of ATP is rapid and/or sudden. In the brain the different CK isoforms constitute an energy shuttle wherein ATP produced in the mitochondria is used by a mitochondrial CK [e.g. ubiquitous mitochondrial creatine kinase (uMi-CK)] to generate PCr, which is then transported and used by a cytoplasmic CK [e.g. brain creatine kinase (CKB)] to regenerate ATP at discrete cellular sites of high ATP turnover. CKB appears to have a role in regenerating ATP needed for the transport of ions and neurotransmitters since CKB has been localized to brain synaptic plasma membranes, possibly coupled to Na+/K+-ATPase and acetylcholine receptor-rich membranes. Expression of CKB is developmentally controlled: in rat, brain CKB protein at birth is extremely low and increases 10-fold until week 4. This reflects the many energy-demanding processes in brain during brain development.Synonyms: B-CK, CKB, Creatine kinase B chain, Creatine kinase B-type, Creatine kinase BB
    Gen-ID
    1152
    NCBI Accession
    NP_001814
    UniProt
    P12277
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