CD55 Antikörper (FITC)

Produktnummer ABIN1106468

Der Maus Monoklonal Anti-CD55 Antikörper wurde für FACS validiert. Er ist geeignet, CD55 in Proben von Human zu detektieren.

Kurzübersicht für CD55 Antikörper (FITC) (ABIN1106468)

Target: CD55 (Complement Decay-Accelerating Factor (CD55))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD55 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Klon: 2C6

Produktdetails anti-CD55 Antikörper (FITC)

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein A agarose

Immunogen: Human adenocarcinoma cell line (PC3)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS, 0.09 % NaN3, 1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C.

Details zu CD55

Target: CD55 (Complement Decay-Accelerating Factor (CD55))

Andere Bezeichnung: CD55 / DAF

Hintergrund: CD55, also known as decay-accelerating factor (DAF), is a GPI-anchored membrane inhibitor of complement. It inhibits complement activation by interfering with the function of C3 and C5 convertases in both the classical and alternative pathways. CD55 is expressed on most cells to protect them from complement-mediated attack. CD55 and other membrane complement regulatory proteins (CD46 and CD59) are frequently overexpressed on cancer cells, possibly as a mechanism for cancer cells to overcome lysis by complement. Virus-receptor interactions have been elucidated for several viruses that use CD55 as an adhesion or invasion receptor, including enterovirus, echovirus, and coxsackie B virus. Moreover, CD55 also interacts with an epidermal growth factor-seven-span transmembrane (EGF-TM7) receptor, CD97. CD97 antigen becomes immediately up-regulated on most leukocytes during activation and is constitutively expressed by macrophages, dendritic cells, and some epithelial tumors.Synonyms: Complement decay-accelerating factor

Gen-ID: 9606

UniProt: P08174

Pathways: Komplementsystem, Regulation of Leukocyte Mediated Immunity