Leptin Receptor Antikörper (Soluble)

Produktnummer ABIN1106239

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Leptin Receptor in WB, IHC (p), IHC (fro) und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Leptin Receptor Antikörper (Soluble) (ABIN1106239)

Target: Leptin Receptor (LEPR)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Leptin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: 2F1

Produktdetails anti-Leptin Receptor Antikörper

Bindungsspezifität: Soluble

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu Leptin Receptor

Target: Leptin Receptor (LEPR)

Andere Bezeichnung: CD295 / Leptin Receptor

Hintergrund: Leptin is a cytokine that is primarily expressed by adipose tissue. Leptin controls food intake by its interaction with the leptin receptor in the brain. Leptin action is mediated and controlled by the leptin receptor, a class I type cytokine receptor. sLR is generated by proteolytic cleavage of membrane-anchored receptors. This indicates that the leptin receptor might have other functions besides transduction. Binding of leptin with sLR increases the bioavailability of leptin in plasma, but also decreases the binding of leptin to membrane bound leptin receptors. For example, when comparing obese and lean individuals, plasma levels of sLR are significantly decreased whereas leptin levels are significantly increased.Synonyms: DB, HuB219, LEP-R, LEPR, OB receptor, OB-R, OBR

Gen-ID: 9606

UniProt: P48357

Pathways: JAK-STAT Signalweg, AMPK Signaling, Feeding Behaviour