C1QA Antikörper (Biotin)

Produktnummer ABIN1105607

Der Maus Monoklonal Anti-C1QA-Antikörper wurde für WB, IF, IHC (fro), EIA und Func validiert. Er ist geeignet, C1QA in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für C1QA Antikörper (Biotin) (ABIN1105607)

Target: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C1QA Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Functional Studies (Func)

Klon: JL-1

Produktdetails anti-C1QA Antikörper (Biotin)

Spezifität: The monoclonal antibody JL-1 recognizes the collagen-like region (CLR) of mouse C1q.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Immunogen: Purified mouse C1q

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu C1QA

Target: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Andere Bezeichnung: C1q A Subunit

Hintergrund: C1q is a 459 kDa molecule consisting of three individual polypeptide chains. The antibody has been generated by immunization of C1q-/- C57BL/6 mice with purified mouse C1q. C1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can also recognize molecular patterns associated with pathogens and it can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE).Synonyms: Complement 1q, Complement C1q, Complement C1q subcomponent subunit A

Gen-ID: 712

NCBI Accession: NP_057075

UniProt: P02745

Pathways: Komplementsystem