beta 2 Adrenergic Receptor Antikörper

Produktnummer ABIN1105514

Der Maus Monoklonal Anti-beta 2 Adrenergic Receptor-Antikörper wurde für EIA, Func und ELISA (Detection) validiert. Er ist geeignet, beta 2 Adrenergic Receptor in Proben von Human, Ratte und Meerschweinchen zu detektieren.

Kurzübersicht für beta 2 Adrenergic Receptor Antikörper (ABIN1105514)

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Reaktivität: Human, Ratte, Meerschweinchen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta 2 Adrenergic Receptor Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA), Functional Studies (Func), ELISA (Detection)

Klon: 6H8

Produktdetails anti-beta 2 Adrenergic Receptor Antikörper

Spezifität: The monoclonal antibody 6H8 recognizes Human beta-2-Adrenoceptor.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Rat, Guinea Pig.

Aufreinigung: Protein G

Immunogen: Free peptide Beta2-H19C

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu beta 2 Adrenergic Receptor

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Andere Bezeichnung: beta-2 Adrenergic Receptor

Hintergrund: The b -adrenoceptors can be divided into b1, b2, b3 and b4-adrenoceptors defined in terms of agonist potencies, b2-adrenoceptors displayed a higher selectivity for nor-adrenaline than for adrenaline. B2-receptors are mainly postsynaptic and are located on a number of tissues including blood vessels, bronchi, GIT, skeletal muscle, liver and mast cell. Activation results in vasodilatation, bronchodilation, relaxation of the GIT, glycogenolysis in the liver, tremor in skeletal muscle and inhibition of histamine release from mast cells. Transduction is via G-proteins coupled to the intracellular second messenger adenylate cyclase. B-receptors are positively coupled to adenylate cyclase via activation of Gs G-protein, however activation of the b2-adrenoceptors results in stimulation and inhibition of adenylate cyclase. The b2-receptor selective agonists are widely used in the treatment of asthma and other related bronchospastic conditions. They are commonly used in the treatment of angina pectoris, cardiac arrhythmia and for the long-term treatment of patients who survive myocardial infarction. B-receptor antagonists have also been used as anti-hypertensive for a number of years. Beta -blockers have also proven useful in the treatment of conditions such as migraine, anxiety disorders, hyperthyroidism, alcohol withdrawal and when applied topically are useful in the treatment of glaucoma and ocular hypertension.Synonyms: ADRB2, ADRB2R, B2AR, Beta-2 adrenoreceptor

Gen-ID: 154

NCBI Accession: NP_000015

UniProt: P07550

Pathways: cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation