beta Amyloid Antikörper (N-Term)

Produktnummer ABIN1105359

Dieses Anti-beta Amyloid-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von beta Amyloid in WB und EIA. Geeignet für Human.

Kurzübersicht für beta Amyloid Antikörper (N-Term) (ABIN1105359)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: NT 5B8

Produktdetails anti-beta Amyloid Antikörper

Bindungsspezifität: N-Term

Sequenz: DAEFRHDS

Spezifität: This antibody recognizes the N-terminal sequence of human beta amyloid peptide 40 and peptide 42.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G affinity purified

Immunogen: Human beta amyloid peptide 1-42

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Double distillated water is recommended and to adjust the final concentration to 1.00 mg/mL.

Buffer: 0.01 M PBS pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Amyloid beta

Hintergrund: Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

Gen-ID: 351

Pathways: Inflammasome