beta Amyloid Antikörper (N-Term)

Produktnummer ABIN1105355

Der Maus Monoklonal Anti-beta Amyloid-Antikörper wurde für EIA und ELISA (Capture) validiert. Er ist geeignet, beta Amyloid in Proben von Human zu detektieren.

Kurzübersicht für beta Amyloid Antikörper (N-Term) (ABIN1105355)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA), ELISA (Capture)

Klon: NT 7H7

Produktdetails anti-beta Amyloid Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody recognizes the N-terminal sequence (DAEFRHDS) of beta amyloid peptides, and full length beta amyloid peptide 40, 42 and 43.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G affinity purified

Immunogen: Full length human beta amyloid peptide 42

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Use double distillated water to reconstitute the antibody.

Buffer: 0.01 M PBS pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Amyloid beta

Hintergrund: Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.

Gen-ID: 351

Pathways: Inflammasome