beta Amyloid Antikörper (N-Term)

Produktnummer ABIN1105349

Der Maus Monoklonal anti-beta Amyloid Antikörper wird verwendet zum Nachweis von beta Amyloid in Proben von Human. Er wurde validiert für IHC (fro).

Kurzübersicht für beta Amyloid Antikörper (N-Term) (ABIN1105349)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: NT 6C8

Produktdetails anti-beta Amyloid Antikörper

Bindungsspezifität: N-Term

Sequenz: DAEFRHDS

Spezifität: This antibody recognizes the N-terminal sequence of beta amyloid peptides.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G affinity purified

Immunogen: The N-terminal sequence of human beta amyloid peptides

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Double distillated water is recommended and to adjust the final concentration to 1.00 mg/mL.

Buffer: 0.01 M PBS pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Amyloid beta

Hintergrund: Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II

Gen-ID: 351

Pathways: Inflammasome