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CD59 Antikörper (AA 31-111)

Name: CD59 Antikörper (AA 31-111)
Brand: antibodies-online
SKU: ABIN1098134
Price: 640.59 EUR
Availability: InStock

CD59 Reaktivität: Human FACS, IHC, ELISA, ICC Wirt: Maus Monoclonal 8D2B8 unconjugated

Western blot analysis using CD59 mAb against human CD59 recombinant protein. (CD59 Antikörper (AA 31-111))

Immunofluorescence analysis of MCF-7 cells using CD59 mouse mAb (green). (CD59 Antikörper (AA 31-111))

Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using CD59 mouse mAb with DAB staining. (CD59 Antikörper (AA 31-111))

IHC

Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using CD59 mouse mAb with DAB staining. (CD59 Antikörper (AA 31-111))

IHC

Black line: Control Antigen (100 ng), Purple line: Antigen(10 ng), Blue line: Antigen (50 ng), Red line: Antigen (100 ng), (CD59 Antikörper (AA 31-111))

ELISA

Flow cytometric analysis of HeLa cells using CD59 mouse mAb (green) and negative control (red). (CD59 Antikörper (AA 31-111))

FACS

Western blot analysis using CD59 mAb against HEK293 (1) and CD59 (AA: 31-111)-hIgGFc transfected HEK293 (2) cell lysate. (CD59 Antikörper (AA 31-111))

Immunofluorescence analysis of Hela cells using CD59 mouse mAb (green). (CD59 Antikörper (AA 31-111))

8 Abbildungen

(2 Referenzen)

Produktnummer ABIN1098134

Datenblatt (PDF)

Target Alle CD59 Antikörper anzeigen

CD59
Bindungsspezifität
15

10

7

6

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 31-111
Reaktivität
128

8

8

7

3

1

1
Human
Wirt
77

60

6

4
Maus
Passende Sekundärantikörper
Klonalität
85

59

1
Monoklonal
Konjugat
72

11

11

11

4

4

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
Dieser CD59 Antikörper ist unkonjugiert
Applikation
88

55

43

35

25

23

20

16

12

12

12

11

11

11

3

3

1

1

1

1
Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Verwendungszweck

CD59 Antibody

Aufreinigung

Purified antibody

Immunogen

Purified recombinant fragment of human CD59 (AA: 31-111) expressed in E. Coli.

Klon

8D2B8

Isotyp

IgG1
anti-CD59 (CD59) (AA 74-110) antibody
CD59 Reaktivität: Human WB, FACS, IF, IHC (p) Wirt: Kaninchen Polyclonal RB56691 unconjugated

anti-CD59 (CD59) (AA 31-111) antibody
CD59 Reaktivität: Human WB, FACS, IHC, ELISA, IF/ICC Wirt: Maus Monoclonal unconjugated

anti-CD59 (CD59) (AA 23-105) antibody
CD59 Reaktivität: Ratte WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-CD59 (CD59) (AA 1-128) antibody
CD59 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 3G6 unconjugated

anti-CD59 (CD59) (AA 26-102) antibody
CD59 Reaktivität: Human WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated

anti-CD59 (CD59) (AA 52-100) antibody
CD59 Reaktivität: Human FACS, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) Wirt: Kaninchen Polyclonal unconjugated

anti-CD59 (CD59) antibody
CD59 Reaktivität: Human WB, IHC, ELISA Wirt: Maus Monoclonal 2E11B6 unconjugated

anti-CD59 (CD59) antibody
CD59 Reaktivität: Human, Maus, Ratte IHC Wirt: Kaninchen Polyclonal unconjugated

anti-CD59 (CD59) (AA 1-128) antibody
CD59 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated

anti-CD59 (CD59) antibody
GMP Grade CD59 Reaktivität: Human FACS Wirt: Maus Monoclonal BRA-10G unconjugated

Applikationshinweise

ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/50 - 1/200

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Alegretti, Mucenic, Merzoni, Faulhaber, Silla, Xavier: "Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients." in: Cellular immunology, Vol. 265, Issue 2, pp. 127-32, (2010) (PubMed).

Ma, Chang, Qin, Sun, Huang, He: "Decreased expression of complement regulatory proteins, CD55 and CD59, on peripheral blood leucocytes in patients with type 2 diabetes and macrovascular diseases." in: Chinese medical journal, Vol. 122, Issue 18, pp. 2123-8, (2009) (PubMed).
Target

CD59

Andere Bezeichnung

CD59 (CD59 Produkte)

Hintergrund

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Molekulargewicht

14.2 kDa

Gen-ID

966

UniProt

P13987

Pathways

Komplementsystem