CD59 Antikörper (AA 31-111)

Produktnummer ABIN1098134

Der Maus Monoklonal Anti-CD59-Antikörper wurde für FACS, IHC, ELISA und ICC validiert. Er ist geeignet, CD59 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für CD59 Antikörper (AA 31-111) (ABIN1098134)

Target: CD59

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD59 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Klon: 8D2B8

Produktdetails anti-CD59 Antikörper

Bindungsspezifität: AA 31-111

Verwendungszweck: CD59 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human CD59 (AA: 31-111) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50 - 1/200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-CD59 Antikörper (ABIN1098134)

Alegretti, Mucenic, Merzoni, Faulhaber, Silla, Xavier: "Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients." in: Cellular immunology, Vol. 265, Issue 2, pp. 127-32, (2010) (PubMed).

Ma, Chang, Qin, Sun, Huang, He: "Decreased expression of complement regulatory proteins, CD55 and CD59, on peripheral blood leucocytes in patients with type 2 diabetes and macrovascular diseases." in: Chinese medical journal, Vol. 122, Issue 18, pp. 2123-8, (2009) (PubMed).

Details zu CD59

Target: CD59

Andere Bezeichnung: CD59

Hintergrund: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Molekulargewicht: 14.2 kDa

Gen-ID: 966

UniProt: P13987

Pathways: Komplementsystem