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CD59 Antikörper (AA 31-111)

Der Maus Monoklonal Anti-CD59-Antikörper wurde für FACS, IHC, ELISA und ICC validiert. Er ist geeignet, CD59 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.
Produktnummer ABIN1098134

Kurzübersicht für CD59 Antikörper (AA 31-111) (ABIN1098134)

Target

Alle CD59 Antikörper anzeigen
CD59

Reaktivität

  • 171
  • 17
  • 13
  • 11
  • 5
  • 5
  • 5
  • 1
  • 1
Human

Wirt

  • 107
  • 95
  • 8
  • 6
Maus

Klonalität

  • 118
  • 95
  • 1
Monoklonal

Konjugat

  • 107
  • 26
  • 14
  • 13
  • 8
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD59 Antikörper ist unkonjugiert

Applikation

  • 107
  • 97
  • 85
  • 48
  • 47
  • 40
  • 32
  • 24
  • 16
  • 14
  • 13
  • 13
  • 11
  • 11
  • 11
  • 8
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Klon

8D2B8
  • Bindungsspezifität

    • 16
    • 16
    • 10
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 31-111

    Verwendungszweck

    CD59 Antibody

    Aufreinigung

    Purified antibody

    Immunogen

    Purified recombinant fragment of human CD59 (AA: 31-111) expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/50 - 1/200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified antibody in PBS with 0.05 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Alegretti, Mucenic, Merzoni, Faulhaber, Silla, Xavier: "Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients." in: Cellular immunology, Vol. 265, Issue 2, pp. 127-32, (2010) (PubMed).

    Ma, Chang, Qin, Sun, Huang, He: "Decreased expression of complement regulatory proteins, CD55 and CD59, on peripheral blood leucocytes in patients with type 2 diabetes and macrovascular diseases." in: Chinese medical journal, Vol. 122, Issue 18, pp. 2123-8, (2009) (PubMed).

  • Target

    CD59

    Andere Bezeichnung

    CD59

    Hintergrund

    This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

    Molekulargewicht

    14.2 kDa

    Gen-ID

    966

    UniProt

    P13987

    Pathways

    Komplementsystem
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