IL13 Receptor alpha 1 Antikörper (Extracellular Domain)

Produktnummer ABIN108718

Dieser Maus Monoklonal Antikörper detektiert spezifisch IL13 Receptor alpha 1 in ELISA, FACS, cELISA und Anta. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für IL13 Receptor alpha 1 Antikörper (Extracellular Domain) (ABIN108718)

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL13 Receptor alpha 1 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Cell-ELISA (cELISA), Antagonist (Anta)

Klon: GM-1E7

Produktdetails anti-IL13 Receptor alpha 1 Antikörper

Bindungsspezifität: Extracellular Domain

Spezifität: GM1E7 recognises IL-13Ralpha1 transiently expressed on the cell surface of transfected BOSC cells as well as the native protein on monocytes (Myrtek et al., 2004).

Aufreinigung: Protein G

Immunogen: genetic immunisation with cDNA encoding human IL13-Ralpha1 (extracellular domain)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C

Informationen zur Lagerung: short term: 2 °C - 8 °C, long term: -20 °C

Details zu IL13 Receptor alpha 1

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Andere Bezeichnung: IL13Ra1

Hintergrund: Interleukin 13 (IL-13) is a T cell derived cytokine involved in the regulation of inflammatory and im-mune responses. IL-13Rα1 together with IL-4Rα forms a functional receptor for both IL-4 and IL-13, which is why these two cytokines share many of their biological activities. The receptor is found on human B cells, monocytes and endothelial cells. However, no functional receptor is expressed on T cells, which explains why IL-13, in contrast to IL-4, fails to induce TH2-cell differentiation.

UniProt: P78552

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response