SIP1 Antikörper (AA 12-280)

Produktnummer ABIN108540

Dieser Anti-SIP1 Antikörper ist ein Maus Monoklonal Antikörper zur Detektion von SIP1 in WB, ELISA, IF, IP, ICC und FACS. Geeignet für Human, Maus und Xenopus laevis. Dieses Primary Antibody wurde in 8+ Publikationen zitiert.

Kurzübersicht für SIP1 Antikörper (AA 12-280) (ABIN108540)

Target: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Reaktivität: Human, Maus, Xenopus laevis

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 2E17

Produktdetails anti-SIP1 Antikörper

Bindungsspezifität: AA 12-280

Aufreinigung: Protein A

Immunogen: His-Gemin 2 fusion protein (amino acids 12 - 280, starting at 2nd methionine)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal antibody dilution should be determined by titration, however as a guideline try:Flow Cyt: Use 1 μg for 106 cellWB: Use at an assay dependent dilution. Detects a band of approximately 34 kDa

Kommentare:

Myeloma, fusion partners: SP2/0

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Purified antibody (from supernatant) containing PBS + 0.1 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-SIP1 Antikörper (ABIN108540)

Sanchez, Dury, Murray, Biondi, Tadesse, El Fatimy, Kothary, Charbonnier, Khandjian, Côté: "A novel function for the survival motoneuron protein as a translational regulator." in: Human molecular genetics, Vol. 22, Issue 4, pp. 668-84, (2013) (PubMed).

Wu, Whye, Glazewski, Choe, Kerr, Lee, Mason, Wang: "Proteomic assessment of a cell model of spinal muscular atrophy." in: BMC neuroscience, Vol. 12, pp. 25, (2011) (PubMed).

Takizawa, Qing, Takaku, Ishida, Morozumi, Tsujita, Kogame, Hirota, Takahashi, Shibata, Kurumizaka, Takeda: "GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination." in: Nucleic acids research, Vol. 38, Issue 15, pp. 5059-74, (2010) (PubMed).

Burnett, Muñoz, Tandon, Kwon, Sumner, Fischbeck: "Regulation of SMN protein stability." in: Molecular and cellular biology, Vol. 29, Issue 5, pp. 1107-15, (2009) (PubMed).

Walker, Rajendra, Saieva, Fuentes, Pellizzoni, Matera: "SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain." in: Human molecular genetics, Vol. 17, Issue 21, pp. 3399-410, (2008) (PubMed).

Morency, Sabra, Catez, Texier, Lomonte: "A novel cell response triggered by interphase centromere structural instability." in: The Journal of cell biology, Vol. 177, Issue 5, pp. 757-68, (2007) (PubMed).

Renvoisé, Khoobarry, Gendron, Cibert, Viollet, Lefebvre: "Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells." in: Journal of cell science, Vol. 119, Issue Pt 4, pp. 680-92, (2006) (PubMed).

Liu, Fischer, Wang, Dreyfuss: "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins." in: Cell, Vol. 90, Issue 6, pp. 1013-21, (1997) (PubMed).

Details zu SIP1

Target: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Andere Bezeichnung: Gemin 2

Hintergrund: Synonyms:
Component of gems 2 antibody,GEMI2_HUMAN antibody,Gemin-2 antibody,gemin2 antibody,SIP 1antibody,SIP-1 antibody,SIP1 antibody,SIP1 delta antibody,SMN interacting protein 1 antibody,SMNinteracting protein 1 delta antibody,SMN-interacting protein 1 antibody,Survival interacting protein 1antibody,Survival of motor neuron protein interacting protein 1 antibody,Survival of motor neuronprotein-interacting protein 1 antibody

Gen-ID: 8487

OMIM: 602595

Pathways: Ribonucleoprotein Complex Subunit Organization, Tube Formation