FLT3 Antikörper (N-Term)
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- Target Alle FLT3 Antikörper anzeigen
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FLT3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Spezifität
- At least three isoforms of FLT3 are known to exist, this antibody will detect all isoforms.
- Aufreinigung
- Affinity chromatography purified via peptide column
- Immunogen
- FLT3 antibody was raised against an 18 amino acid synthetic peptide near the center of human FLT3.
- Isotyp
- IgG
- Top Product
- Discover our top product FLT3 Primärantikörper
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- Applikationshinweise
- FLT3 antibody can be used for detection of FLT3 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
- Kommentare
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(NT) Fms-like tyrosine kinase 3
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- FLT3 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.
- Haltbarkeit
- 12 months
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- Target
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
- Andere Bezeichnung
- FLT3 (FLT3 Produkte)
- Synonyme
- FLT3 antikoerper, B230315G04 antikoerper, CD135 antikoerper, Flk-2 antikoerper, Flk2 antikoerper, Flt-3 antikoerper, Ly72 antikoerper, wmfl antikoerper, FLK-2 antikoerper, FLK2 antikoerper, STK1 antikoerper, fms related tyrosine kinase 3 antikoerper, FMS-like tyrosine kinase 3 antikoerper, fms-related tyrosine kinase 3 antikoerper, FLT3 antikoerper, Flt3 antikoerper
- Hintergrund
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FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity.
Synonyms: Fms-like tyrosine kinase 3, receptor-type tyrosine-protein kinase FLT3, CD135, FL cytokine receptor, fetal liver kinase 2, stem cell tyrosine kinase 1 - Molekulargewicht
- 109 kDa
- Gen-ID
- 2322
- NCBI Accession
- NP_004110
- Pathways
- RTK Signalweg
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