Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

LAMP2 Antikörper (APC)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch LAMP2 in FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.
Produktnummer ABIN1027702

Kurzübersicht für LAMP2 Antikörper (APC) (ABIN1027702)

Target

Alle LAMP2 Antikörper anzeigen
LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Reaktivität

  • 121
  • 78
  • 38
  • 16
  • 4
  • 3
  • 2
  • 1
Human

Wirt

  • 97
  • 39
  • 36
Maus

Klonalität

  • 90
  • 81
Monoklonal

Konjugat

  • 75
  • 20
  • 17
  • 13
  • 8
  • 6
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LAMP2 Antikörper ist konjugiert mit APC

Applikation

  • 116
  • 59
  • 58
  • 48
  • 44
  • 33
  • 28
  • 14
  • 13
  • 13
  • 11
  • 7
  • 5
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

H4B4
  • Verwendungszweck

    Anti-Hu CD107b APC

    Spezifität

    The mouse monoclonal antibody H4B4 recognizes an extracellular/luminal epitope of CD107b / LAMP-2, an extensively glycosylated 100-120 kDa widely expressed lysosome-associated protein.

    Keine Kreuzreaktivität

    Maus, Ratte

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    Immunogen

    Human PBMC

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Intracellular and extracellular staining.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Rekonstitution

    No reconstitution is necessary.

    Buffer

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.
    Avoid prolonged exposure to light.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Meade, Wilson, Holmes, de Wynter, Brett, Straszynski, Ballard, Trapani, McDermott, Cook: "Proteolytic activation of the cytotoxic phenotype during human NK cell development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 2, pp. 803-13, (2009) (PubMed).

    Guia, Cognet, de Beaucoudrey, Tessmer, Jouanguy, Berger, Filipe-Santos, Feinberg, Camcioglu, Levy, Al Jumaah, Al-Hajjar, Stephan, Fieschi, Abel, Brossay, Casanova, Vivier: "A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo." in: Blood, Vol. 111, Issue 10, pp. 5008-16, (2008) (PubMed).

    Apte, Baz, Groves, Kelso, Kienzle: "Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 45, pp. 17475-80, (2008) (PubMed).

    Kannanganat, Ibegbu, Chennareddi, Robinson, Amara: "Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells." in: Journal of virology, Vol. 81, Issue 16, pp. 8468-76, (2007) (PubMed).

    Denzer, van Eijk, Kleijmeer, Jakobson, de Groot, Geuze: "Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 3, pp. 1259-65, (2000) (PubMed).

  • Target

    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

    Andere Bezeichnung

    CD107b

    Hintergrund

    Lysosomal associated membrane protein 2,CD107b (lysosome-associated membrane protein-2, LAMP-2), together with CD107a / LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa.,LAMP-2, LAMPB

    Gen-ID

    3920

    UniProt

    P13473

    Pathways

    Autophagie
Sie sind hier:
Chat with us!