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anti-Human Fatty Acid Synthase Antikörper:
anti-Mouse (Murine) Fatty Acid Synthase Antikörper:
anti-Rat (Rattus) Fatty Acid Synthase Antikörper:
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Chicken Polyclonal Fatty Acid Synthase Primary Antibody für ICC, IF - ABIN152891
Gao, Bryzgalova, Hedman, Khan, Efendic, Gustafsson, Dahlman-Wright et al.: Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal ... in Molecular endocrinology (Baltimore, Md.) 2006
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Human Polyclonal Fatty Acid Synthase Primary Antibody für IF (p), IHC (p) - ABIN687382
Zhu, Luo, Wang, Yu, Wang, Shi, Sun, Lin, Li: Inhibition of FASN reduces the synthesis of medium-chain fatty acids in goat mammary gland. in Animal : an international journal of animal bioscience 2014
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Dog (Canine) Monoclonal Fatty Acid Synthase Primary Antibody für IF, WB - ABIN968278
Chirala, Huang, Jayakumar, Sakai, Wakil: Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities. in Proceedings of the National Academy of Sciences of the United States of America 1997
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Dog (Canine) Monoclonal Fatty Acid Synthase Primary Antibody für IF, WB - ABIN968279
Jayakumar, Tai, Huang, al-Feel, Hsu, Abu-Elheiga, Chirala, Wakil: Human fatty acid synthase: properties and molecular cloning. in Proceedings of the National Academy of Sciences of the United States of America 1995
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Human Monoclonal Fatty Acid Synthase Primary Antibody für IF, IHC (p) - ABIN560848
Kristiansen, Rose, Geisler, Fritzsche, Gerhardt, Lüke, Ladhoff, Knüchel, Dietel, Moch, Varga, Theurillat, Gorr, Dahl: Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype. in British journal of cancer 2010
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Human Monoclonal Fatty Acid Synthase Primary Antibody für IF, ELISA - ABIN560849
Oliveras-Ferraros, Vazquez-Martin, Fernández-Real, Menendez: AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase. in Biochemical and biophysical research communications 2008
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Human Polyclonal Fatty Acid Synthase Primary Antibody für ICC, IF - ABIN4310707
Huang, Bell, Okamura, Kim, Mohney, Guerrero-Preston, Ratovitski: Phospho-ΔNp63α/SREBF1 protein interactions: bridging cell metabolism and cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012
Fasn-1 regulates antimicrobial peptide (zeige cAMP Antikörper) nlp-29 expression in a WNK-1 (zeige WNK1 Antikörper) and gck (zeige GCK Antikörper)-3 dependent manner.
Genetic interactions at the cell-autonomous level, where glycolytic enzymes or Glo1 (zeige GLO1 Antikörper) were manipulated in FASN mutant cells, revealed that this sugar-dependent size reduction is a direct consequence of MG-derived-AGE accumulation
HER2 (zeige ERBB2 Antikörper)-FASN lipogenic axis delineates a group of breast cancer patients that might benefit from treatment with therapeutic regimens containing FASN inhibitors
FASN expression is down-regulated by miR (zeige MLXIP Antikörper)-15a and miR-16 (zeige GDE1 Antikörper)-1 in breast cancer cells, regulating cell proliferation.
These findings implicate Spot14 (zeige THRSP Antikörper) as a direct protein enhancer of FASN catalysis in the mammary gland during lactation when maximal MCFA production is needed.
High FASN expression is associated with prostate cancer growth.
We show that elevated levels of PPARG (zeige PPARG Antikörper) strongly correlate with elevation of FASN in human prostate cancer (CaP) and that high levels of PPARG (zeige PPARG Antikörper)/FASN and PI3K (zeige PIK3CA Antikörper)/pAKT (zeige AKT1 Antikörper) pathway activation confer a poor prognosis.These data suggest that CaP patients could be stratified in terms of PPARG (zeige PPARG Antikörper)/FASN and PTEN levels to identify patients with aggressive CaP who may respond favorably to PPARG (zeige PPARG Antikörper)/FASN inhibition.
High FASN expression is associated with meningioma and schwannoma.
our findings show that microRNA-195 inhibits pancreatic cancer cell proliferation and invasion by regulating the fatty acid synthase/Wnt (zeige WNT2 Antikörper) signaling pathway, suggesting a tumor suppressive role for microRNA-195 in the development and progression of pancreatic cancer. Thus, inhibiting fatty acid synthase by microRNA-195 may serve as a novel therapeutic approach for the treatment of pancreatic cancer.
Inhibition of FASN can decrease the levels of IGFBP1 (zeige IGFBPI Antikörper), and the expression, activity, and ubiquitination of HIF-1alpha (zeige HIF1A Antikörper). Inhibition of FASN can suppress migration, invasion and healing of hepatoma carcinoma cells by decreasing HIF-1alpha (zeige HIF1A Antikörper), and IGFBP1 (zeige IGFBPI Antikörper).
The involvement of SREBP-1c (zeige SREBF1 Antikörper) and ChREBP (zeige MLXIPL Antikörper) in FASN promoter histone modification.Histone acetylation affects FASN transcription by influencing ChREBP (zeige MLXIPL Antikörper)-binding carbohydrate-responsive elements.
Fatty acid synthase (FASN) inhibitors reduce proliferation and promote apoptosis in high FASN producers lymphatic endothelial cells (HDLEC) cells.
FASN gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 (zeige INSIG2 Antikörper) is a promising marker for FA composition
In this study, we investigated the FASN gene expression pattern and corresponding DNA methylation (zeige HELLS Antikörper) status in the inner layer of backfat from Jinhua pigs at different developmental stages.
calculated a 4.5 angstrom-resolution map of fatty acid synthase, and placed homologous template structures of all individual catalytic domains responsible for the cyclic elongation of fatty acid chains into the electron density
study determined fatty acid synthase crystal structure at 3.2 angstrom resolution covering five catalytic domains; structure reveals a complex architecture of alternating linkers and enzymatic domains
FASN regulates the pathogenicity of Th17 cells.
genetic deletion of FASN totally suppresses hepatocarcinogenesis driven by AKT and AKT/c-Met protooncogenes in mice.
Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn) promoter specifically in refeeding states.
study demonstrates that co-activation of AKT (zeige AKT1 Antikörper) and c-Met induces hepatocellular carcinoma development that depends on the mTORC1/FASN pathway.
Inhibition of G-protein-coupled Receptor Kinase 2 (zeige ADRBK1 Antikörper) Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
These findings suggest that activation of TSHR (zeige TSHR Antikörper) directly inhibits FASN expression in mature adipocytes, possibly mediated by PKA and ERK (zeige EPHB2 Antikörper)
UCP2 (zeige UCP2 Antikörper)-induced fatty acid synthase promotes NLRP3 (zeige NLRP3 Antikörper) inflammasome activation during sepsis
FASN plays an important role in exercise-mediated cognitive enhancement, which might be associated to its role in modulating exercise-induced stimulation of neurogenesis.
FASN is essential for the development, functional competence, and maintenance of the lactating mammary gland.
Gamma-tocotrienol showed attenuation of triglyceride through effect on fatty acid synthase, sterol regulatory element-binding transcription factor 1 (zeige SREBF1 Antikörper), stearoyl CoA desaturase 1 (zeige SCD Antikörper), and carnitine palmitoyl transferase 1A gene expression in Hepa 1-6 cells.
FASN single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
g.841G>C SNP of FASN gene is associated with fatty acid composition in beef cattle.
Results indicate that Fatty acid synthase (FASN) may be used as a candidate gene affecting intramuscular fat content in Datong yaks.
It was suggested that two cattle breeds have an advantage in terms of genotype and haplotype distribution of the FASN gene; a single polymorphism might be a potential marker for breed discrimination.
study evaluated the contributions of polymorphisms of FASN and SCD (zeige SCD Antikörper) genes on fatty acid composition in muscle in two different populations: 1189 and 1058 Japanese Black cattle from the Miyagi and the Yamagata populations
The five exonic single nucleotide polymorphisms of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents.
Results suggest that SCD (zeige SCD Antikörper) and FASN are strong candidate genes influencing fatty acid composition in beef cattle.
The effects of genetic polymorphisms of liver X receptor, alpha (LXR (zeige NR1H3 Antikörper)), stearoyl-CoA desaturase (SCD (zeige SCD Antikörper)), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
In ruminants, FASN may be regulated between the ratio between two transcripts. The small transcript is mostly produced in tissues with low fatty acid synthesis.
Polymorphisms within the FASN gene are associated with milk-fat content.
The results suggested that LXR (zeige NR1H3 Antikörper) regulates FASN promoter activity through direct interaction with the LXR (zeige NR1H3 Antikörper) response element as well as through increasing SREBP1 (zeige SREBF1 Antikörper) abundance.
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
fatty acid synthase
, fatty acid synthase Fas
, Fatty acid synthase Fas
, Fatty Acid SyNthase family member (fasn-1)
, fatty-acid synthase
, fatty-acid synthase II
, fatty-acid synthase fas
, fatty acid synthetase
, short chain dehydrogenase/reductase family 27X, member 1