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anti-Human CAMKK2 Antikörper:
anti-Mouse (Murine) CAMKK2 Antikörper:
anti-Rat (Rattus) CAMKK2 Antikörper:
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Human Polyclonal CAMKK2 Primary Antibody für IHC (p), WB - ABIN1882069
Hsu, Chen, Lee, Chi, Cheng, Chen: Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. in The Journal of biological chemistry 2001
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Human Polyclonal CAMKK2 Primary Antibody für IF (p), IHC (p) - ABIN716426
Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. in Scientific reports 2016
Show all 3 Pubmed References
Human Monoclonal CAMKK2 Primary Antibody für ELISA, WB - ABIN524083
Kou, Sartoretto, Michel: Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. in The Journal of biological chemistry 2009
Human Monoclonal CAMKK2 Primary Antibody für IP, ELISA - ABIN564643
Karacosta, Foster, Azabdaftari, Feliciano, Edelman: A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression. in The Journal of biological chemistry 2012
Human Polyclonal CAMKK2 Primary Antibody für IP, WB - ABIN950067
Krishan, Richardson, Sahni: The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells. in Biochimica et biophysica acta 2016
Human Polyclonal CAMKK2 Primary Antibody für ICC, IF - ABIN4287593
Massie, Lynch, Ramos-Montoya, Boren, Stark, Fazli, Warren, Scott, Madhu, Sharma, Bon, Zecchini, Smith, Denicola, Mathews, Osborne, Hadfield, Macarthur, Adryan, Lyons, Brindle, Griffiths, Gleave et al.: The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. ... in The EMBO journal 2011
14-3-3gamma protein directly interacts with the kinase domain of CaMKK2 and the region containing the inhibitory phosphorylation site Thr (zeige TRH Antikörper)(145) within the N-terminal extension. CaMKK isoforms differ in their 14-3-3 (zeige YWHAQ Antikörper)-mediated regulations and the interaction between 14-3-3 protein (zeige YWHAE Antikörper) and the N-terminal 14-3-3 (zeige YWHAQ Antikörper)-binding motif of CaMKK2 might be stabilized by small-molecule compounds.
CAMKK2 exhibited the strongest associations with HIV-associated sensory neuropathy (HIV-SN), with two SNPs and six haplotypes predicting SN status in black Southern Africans.
Study used three cognitive tasks and fMRI to provide convergent evidence of a link between the rs1063843 SNP of CAMKK2 and the function of the dorsolateral prefrontal cortex. In addition, this polymorphism was associated with the function of the striatum during a working memory task.
Data suggest that CAMKK2 is highly expressed in high-grade ovarian cancer and ovarian cancer cell lines; CAMKK2 directly activates Akt1 by phosphorylation at Thr-308 in a Ca2+/calmodulin-dependent manner; CAMKK2 knockdown or inhibition decreases Akt1 phosphorylation at Thr-308 and Ser-473. (CAMKK2 = calcium/calmodulin dependent protein kinase kinase 2; AKT1 = AKT serine/threonine kinase 1)
Single nucleotide polymorphism in CAMKK2 gene is associated with pulmonary non-tuberculous mycobacterial disease.
This study showed that the expression level of CAMKK2 could be regulated by promoter methylation. CAMKK2 serves as a prognostic marker in gliomas and could be a potential therapeutic target in gliomas.
For the first time, we showed that rs1063843, a single nucleotide polymorphism located in the CAMKK2 gene, is highly associated with bipolar disorder
Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK (zeige PRKAA1 Antikörper) but not of CaMKIalpha (zeige CAMK1 Antikörper).
Clopidogrel diminishes TNFalpha (zeige TNF Antikörper)-stimulated VCAM-1 (zeige VCAM1 Antikörper) expression at least in part via HO-1 (zeige HMOX1 Antikörper) induction and CaMKKbeta/AMPK (zeige PRKAA1 Antikörper)/Nrf2 (zeige GABPA Antikörper) pathway in endothelial cells.
CaMKK2 (and Nup62 (zeige NUP62 Antikörper)) are required for optimal androgen receptor (zeige AR Antikörper) transcriptional activity in castrate resistant prostate cancer cells.
we demonstrated that systemic administration of the small molecule CaMKK2 inhibitor, STO (zeige NSD1 Antikörper)-609, to irradiated mice enhanced Hematopoietic stem and progenitor cells (HSPCs)recovery and improved survival. These findings identify CaMKK2 as an important regulator of HSPC (zeige PSMA7 Antikörper) regeneration and demonstrate CaMKK2 inhibition is a novel approach to promoting hematopoietic recovery after BM injury.
loss of blood-brain barrier proteins, inactivation of survival gene expression such as B-cell lymphoma 2 (Bcl-2 (zeige BCL2 Antikörper)) and an increase in inflammatory cytokines in the serum were observed after stroke with CaMKK beta inhibition. We demonstrate that CaMKK beta is neuroprotective in stroke in aged mice
CaMKK2 as a molecular rheostat for insulin (zeige INS Antikörper) action.
CaMKK2 Inhibits C2C12 Myoblasts Proliferation and Differentiation through AMPK (zeige PRKAA1 Antikörper). Overexpression of CaMKK2 Inhibits Muscle Regeneration in Vivo.
In summary, we demonstrate a new mechanism of calcium dependent antibacterial strategy in E. coli infected macrophages, which requires autophagy enhancement mediated by activation of CaMKKbeta, ERK (zeige EPHB2 Antikörper), AMPK (zeige PRKAA1 Antikörper) and FoxO1 (zeige FOXO1 Antikörper).
CaMKKbeta exerts protective effects on cardiac adaptive energy pooling against pressure-overload possibly through phosphorylation of AMPK and by upregulation of PGC-1alpha.
Results demonstrated that genetically inhibiting the CaMKK pathway via CaMKKbeta or CaMK IV (zeige CAMK4 Antikörper) is detrimental in the response of female mice to cerebral ischemia
a novel function for CaMKK2 in bone remodeling and highlight the potential for its therapeutic inhibition as a valuable bone anabolic strategy that also inhibits OC differentiation in the treatment of osteoporosis.
Flow-enhanced sirtuin (zeige SIRT1 Antikörper) (SIRT)1 (zeige SIRT1 Antikörper) stability is primarily mediated by CaMKKbeta phosphorylation of sirtuin SIRT1 (zeige SIRT1 Antikörper) at Ser (zeige SIGLEC1 Antikörper)-27 and Ser (zeige SIGLEC1 Antikörper)-47.
amino acid starvation regulates autophagy in part through an increase in cellular Ca(2 (zeige CA2 Antikörper)+) that activates a CaMKK-beta-AMPK (zeige PRKAA1 Antikörper) pathway and inhibits mTORC1, which results in ULK1 (zeige ULK1 Antikörper) stimulation
the expression, but not the kinase activity, of AMPK (zeige PRKAA1 Antikörper) and CaMKKbeta is necessary for ADP signaling to eNOS (zeige NOS3 Antikörper)
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.
CAMKK beta protein
, caM-KK 2
, caM-KK beta
, caM-kinase kinase 2
, caM-kinase kinase beta
, calcium/calmodulin-dependent protein kinase beta
, calcium/calmodulin-dependent protein kinase kinase 2
, caMKK 2
, caMKK beta
, calcium/calmodulin-dependent protein kinase kinase beta
, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
, protein-tyrosine kinase
, calcium/calmodulin-dependent protein kinase II beta
, calcium/calmodulin-dependent protein kinase kinase 2, beta
, calcium/calmodulin-dependent protein kinase kinase 2-like
, Ca+/Calmodulin-dependent protein kinase kinase beta (CaM-kinase kinase beta)
, CaM-kinase kinase beta
, calcium/calmodulin-dependent protein kinase 2 beta