anti-Adiponectin Receptor 2 (ADIPOR2) Antikörper

Human Adiponectin Receptor 2 (ADIPOR2) Interaktionspartner

1. There were no significant associations involving ADIPOR2 with diabetes and hypertriglyceridemia in an admixed Latin American population.

2. the findings of the present case-control study further exemplify the role of AdipoR2 genetic polymorphisms (rs10773989 and rs1044471) and its protein expression in colorectal carcinogenesis and advancement.

3. Two polymorphisms, rs2241766 in ADIPOQ gene and rs10773989 in ADIPOR2 gene, especially under the recessive model of inheritance, played independent leading roles in susceptibility to myocardial infarction in Han Chinese.

4. The results indicated that globular adiponectin inhibited the prooncogenic effects of leptin via AdipoR2-mediated suppression of UHRF1

5. Variants of ADIPOR2 could be a determinant for higher FFA levels, and among Chinese Han population, carriers of the CT and TT genotypes for rs2370055 even with normal glucose levels may have significantly higher insulin resistance susceptibility.

6. We conclude that the PAQR-2 and AdipoR2 proteins share an evolutionarily conserved function that maintains membrane fluidity in the presence of exogenous saturated fatty acids.

7. Renoprotection of adiponectin is associated with improvement of the endothelial dysfunction, reduction of oxidative stress, and upregulation of endothelial nitric oxide synthase expression through activation of adenosine 5'-monophosphate-activated protein kinase by AdipoR1 and activation of peroxisome proliferator-activated receptor (PPAR)-alpha signaling pathway by AdipoR2. [review]

8. crystal structure of ADIPOR2 bound to a FFA molecule and show that ADIPOR2 possesses intrinsic basal ceramidase activity that is enhanced by adiponectin

9. Adiponectin stimulates cPLA2 and COX-2 expression via AdipoR1/2-dependent activation of PKC/NADPH oxidase/mitochondria resulting in ROS accumulation, p300 phosphorylation, and histone H4 acetylation.

10. These results indicate that miR-150 can attenuate oxidized low-density lipoprotein - induced lipid accumulation in macrophages via promotion of cholesterol efflux. The suppressive effects of miR-150 on macrophage foam cell formation are mediated through targeting of AdipoR2.

11. Decreased expression of ADIPOR2 is associated with polycystic ovary syndrome.

12. Strong Functional Association of adipor2 and cdh13 with adipoq

13. PCR results showed expression of adiponectin, AdipoR1, AdipoR2, follicle-stimulating hormone receptor (FSHR), and luteinizing hormone receptor (LHR) in granulosa cells (GCs). After controlling body mass index (BMI) values, qRT-PCR demonstrated a decreased expression of adiponectin system in GCs of polycystic ovary syndromepatients compared to those in controls

14. Endometriotic stromal cell proliferation is linked to increased expression of AdipoR2 (and AdipoR1) gene receptor expression.

15. Results identified miR-375 and its direct target, ADIPOR2 as androgen regulated molecules suggesting an important role in the mechanism of the increase in visceral fat mass and the associated insulin resistance caused by testosterone deficiency.

16. Two ADIPOR2 SNPs (rs11061925 and rs929434) were associated with fasting plasma triglyceride concentrations in the entire sample of HIV-infected patients.

17. In conclusion, neutrophil AdipoRs (AdipoR1, AdipoR2) upregulation was associated with early stages of vascular injury, hypertension severity, and low serum levels of adiponectin

18. Results demonstrate that the non-conserved N-terminal trunks dictate the cell-surface expression and temporal signaling profiles of AdipoR1 and AdipoR2.

19. Data indicate the thermal stability of purified N-terminally truncated mutants of adiponectin receptors AdipoR1 and AdipoR2.

20. This study indicated that ApN may play a role in the progression of colorectal adenomatous polyps to carcinoma through actions on adipo-R1 and adipo-R2 receptors.

Mouse (Murine) Adiponectin Receptor 2 (ADIPOR2) Interaktionspartner

1. these results demonstrate that AdipoR1 and AdipoR2 exhibit overlapping and distinct effects in skeletal muscle consistent with enhanced adiponectin sensitivity but these appear insufficient to ameliorate established obesity-induced adiponectin resistance.

2. macrophage polarization is a key determinant regulating AdipoR expression and differential APN-mediated macrophage inflammatory responses

3. AdipoR1, but not AdipoR2 deficiency, leads to diet-induced metabolic dysfunction, revealing that these receptors have highly divergent roles in vascular and metabolic homeostasis

4. Data suggest GnRH (gonadotropin-releasing hormone) neurons in forebrain express AdipoR2 (not AdipoR1); adiponectin/AdipoR2 signal transduction via protein kinase C zeta down-regulates neurotransmission in subpopulation of GnRH neurons.

5. These results prove that elevation of adiponectin and/or adipoR2 expression via gene transfer is an effective approach in managing obesity epidemics.

6. APN, AdipoR1, and AdipoR2 exist in human and mouse retinas and retinal APN and AdipoR1 protein levels are elevated in type 1 diabetes mellitus mice.

7. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue.

8. Human biosynthetic insulin had little or no effect in the regulation of AdipoR1 expression in 3T3-L1 cells, but significantly up-regulated AdipoR2 mRNA level in a biphasic manner.

9. Gene expression of adiponectin and AdipoR1/AdipoR2 receptors gradually increases during the wound healing process.

10. The messenger RNA expression levels of hepatic adiponectin receptor (AdipoR)-1 and AdipoR2 and skeletal muscular AdipoR1 were up-regulated by tiliroside treatment.

11. This study demonistrated that AdipoR2 is expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin.

12. Adipoq signaling has a role in preimplantation embryo development and uterine receptivity.

13. investigation of expression and localization of Adipor2 & Adipor1 during embryo development

14. the adiponectin receptor 2 (AdipoR2) was differentially regulated by alcohol in the anterior cingulate cortex in a K-ras-dependent manner

15. Data suggest that low adiponectin receptors 1 and 2 in visceral adipocytes and adipose tissue and further suppression in adipose tissue of insulin-resistant animals indicate disturbed adiponectin bioactivity.

16. Liver steatosis is associated with downregulation of AdipoR2 and a reduction of AdipoR2 in the liver and with a reduction of serum adiponectin in the obese C57BL mouse.

17. the expression of AdipoR2 and (mainly) AdipoR1 in the mouse adrenal cortex and the adrenocortical cell line Y-1 was detected.

18. cloning of cDNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning [AdipoR1 & AdipoR2]

19. Growth hormone is a positive regulator of AdipoR2.

20. adiponectin receptor expression is regulated by insulin and Foxo1

Pig (Porcine) Adiponectin Receptor 2 (ADIPOR2) Interaktionspartner

1. The ADIPOR2 c.*112G>A SNP was associated with the total number of piglets born and litter weight at weaning.

2. This study demonstrated the presence of adiponectin and its receptors in the uteri, conceptuses, and trophoblasts of pregnant pigs and that the local adiponectin system is dependent on the stage of pregnancy.

3. study demonstrated that adiponectin and adiponectin receptors 1 and 2 messenger RNAs and proteins are present in the porcine hypothalamus and that their expression levels are determined by the pig's endocrine status related to the oestrous cycle

4. This study demonstrated the presence of adiponectin, AdipoR1 and AdipoR2 genes and proteins in the porcine uterus and the effect of the stage of the oestrous cycle on the expression of the adiponectin system.

5. Data indicate that AdipoR1 and AdipoR2 mRNAs and proteins are present in the porcine pituitary and that adiponectin receptors expression is dependent on endocrine status of the animals.

6. The cloning and characterization of adiponectin, ADIPOR1, and ADIPOR2 are reported.

7. Insulin regulates the expression of adiponectin and adiponectin receptors in porcine adipocytes.

8. SNPs and haplotypes that are associated with large litter size, fewer stillborn and mummified piglets and shorter weaning-to-oestrus intervals.

Cow (Bovine) Adiponectin Receptor 2 (ADIPOR2) Interaktionspartner

1. Low level expression of adiponectin mRNA was found in all areas of bovine mammary gland tissues examined. AdipoR1 and AdipoR2 mRNAs were also detected in mammary tissues and their expression was particularly prominent in the parenchyma and cistern.

2. The physiologic status of the ovary has significant effects on the natural expression patterns of adiponectin and its receptors in follicular and luteal cells of bovine ovary.

Zebrafish Adiponectin Receptor 2 (ADIPOR2) Interaktionspartner

1. Adiponectin and adiponectin receptor genes are coexpressed during zebrafish embryogenesis and regulated by food deprivation