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This study demonstrates Pellino 1 (PELI1) as an important modulator that exerts opposite regulatory functions on apoptosis and necroptosis, two distinct forms of regulated cell death mechanisms.
The study demonstrates that cytosolic Pellino-1-mediated K63-linked ubiquitination of IRF5 (zeige IRF5 Proteine) in M1 macrophages regulates glucose intolerance in obesity, suggesting a cytosolic mediator function of Pellino-1 in TLR4 (zeige TLR4 Proteine)/IFN-gamma (zeige IFNG Proteine) receptor-IRF5 (zeige IRF5 Proteine) axis during M1 polarization.
Pellino 1 expression acts as an inhibitory signal of the homeostatic regulation of mitotic cell cycle and checkpoint, and thus contributes to the initiation and progression of neoplastic chromosome aneuploidy.
Pellino-1 overexpression activated PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) and ERK (zeige EPHB2 Proteine) signaling pathways and elicited an epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) phenotype of lung adenocarcinoma cells. Pellino-1-mediated EMT (zeige ITK Proteine) was demonstrated through morphology, the upregulation of Vimentin (zeige VIM Proteine), Slug and Snail (zeige SNAI1 Proteine) expression and the downregulation of E-cadherin (zeige CDH1 Proteine) and beta-catenin (zeige CTNNB1 Proteine) expression.
Results indicate that Pellino-1 contributes to lung oncogenesis through the overexpression of inhibitor of apoptosis protein 2 (cIAP2) and promotion of cell survival and chemoresistance.
Our results suggest that PELI1 might participate in B-cell maturation (zeige TNFRSF17 Proteine) or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages
The combination of low Pellino3 levels together with high and inducible Pellino1 expression may be an important determinant of the degree of inflammation triggered upon Toll-like receptor 2 engagement by Helicobacter pylori and/or its components, contributing to Helicobacter pylori-associated pathogenesis by directing the incoming signal toward an NF-kB-mediated proinflammatory response.
Our observations suggested that Peli-1 gene polymorphism rs329498 might contribute to SLE susceptibility in Chinese Han Population.
The study results in the Chinese Han population showed that PELI1 is a member of a constellation of genetic factors that may contribute to the pathogenesis of systemic lupus erythematosus.
Increased PELI1 expression and subsequent induction of BCL6 (zeige BCL6 Proteine) promotes lymphomagenesis.
Peli1 is a proangiogenic molecule that acts downstream of VEGF (zeige VEGFA Proteine)-Flk-1 (zeige KDR Proteine) and restores angiogenesis and enhances skin flap (zeige ALOX5AP Proteine) survivability.
a novel miR (zeige MLXIP Proteine)-155-Peli1-c-Rel (zeige NFkBP65 Proteine) pathway that specifically regulates Tfh cell generation and function.
These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase (zeige MAPK1 Proteine) signaling by suppressing Pellino 1-mediated K63-linked ubiquitination of cIAP2 (zeige BIRC3 Proteine), K48-linked ubiquitination, and degradation of TRAF3 (zeige TRAF3 Proteine).
Pellino1 interacts with the transcription factor Deformed Epidermal Autoregulatory Factor 1 (DEAF1 (zeige DEAF1 Proteine)).
Peli1 is a microglia-specific mediator of autoimmune neuroinflammation that works by regulating Traf3 (zeige TRAF3 Proteine) degradation
These results demonstrate that the ligands that signal via MyD88 (zeige MYD88 Proteine) do not always employ the same protein kinase (zeige CDK7 Proteine) to activate Pellino 1 and show that the activiation of NF-kappaB (zeige NFKB1 Proteine) and mitogen-activated protein kinases.
Peli1 as a critical factor in the maintenance of peripheral T cell tolerance and demonstrate a previously unknown mechanism of c-Rel (zeige NFkBP65 Proteine) regulation.
Pellino-1 protein may have a cellular function distinct from previously identified functions.
IKKepsilon (zeige IKBKE Proteine)/TBK1 (zeige TBK1 Proteine) mediate the activation of Pellino 1's E3 ligase activity, as well as inducing the transcription of its gene and protein expression in response to TLR3 (zeige TLR3 Proteine) and TLR4 (zeige TLR4 Proteine) agonists.
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (By similarity).
E3 ubiquitin-protein ligase pellino homolog 1
, pellino homolog 1
, pellino-related intracellular-signaling molecule
, protein pellino homolog 1
, pellino 1
, pellino protein
, pellino E3 ubiquitin protein ligase 1 L homeolog
, pellino E3 ubiquitin protein ligase 1 S homeolog
, pellino homolog 1b