anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) Antikörper

Cow (Bovine) Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaktionspartner

1. Differential expression of CD25 and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.

2. IDO may be involved in downregulating immune responses to M. avium subsp. paratuberculosis and other virulent mycobacteria, which may be an example of the pathogen harnessing host immunoregulatory pathways to aid survival.

3. INDO participates in IFN-gama-induced death of bovine luteal cells, through a mechanism that involves degradation of tryptophan, thereby reducing tryptophan concentrations to a point insufficient to meet luteal cells needs

Rhesus Monkey Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaktionspartner

1. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8+ T cells from mesentric lymph nodes.

Human Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaktionspartner

1. Study reports that unstimulated human pericytes (PCs) can directly present alloantigen to effector memory T cells (TEM) and IFN-gamma-activated PCs (gamma-PCs) suppress TEM proliferation but not cytokine production or signaling and conclude that immunosuppressive properties of human PCs are not intrinsic but instead result from IFN-gamma-induced IDO1-mediated tryptophan depletion.

2. IDO1 is an efficient mammalian nitrite reductase that is capable of generating NO under anaerobic conditions.

3. Expression of IDO1 in the intestinal epithelial promotes secretory cell differentiation, via Ahr/Notch signaling, and mucus production, to alter muscus-associated bacteria.

4. Data show that although humans possess two indoleamine 2,3-dioxygenase 1 (IDO) isozymes, IDO1 and IDO2, human cells of various origins require IDO1 but not IDO2 for IFN-gamma-induced cell-autonomous immunity to T. gondii.

5. IDO1 deficiency is related to the pathogenesis of IUGR and PE

6. EMT in clinical prostate cancer is accompanied by upregulated expression of IDO1 and an increased number of regulatory T cells

7. The expression levels of IDO-1 and PD-L1 on licensed mesenchymal stem cells (MSCs), not VCAM-1, ICAM-1 or BST-2 on licensed MSCs, correlated with MSC suppression of third-party T-cell proliferation.

8. IDO-1 is commonly expressed by non-small cell lung cancers... its frequent coexpression with PD-L1 may account for the increased efficacy seen with dual blockade of PD-1/PD-L1 and IDO in clinical studies.

9. A urine-based mRNA biomarker study revealed the diagnostic potential of IDO gene expression in urine of men at risk of prostate cancer development.

10. Indoleamine 2, 3-dioxygenase 1 (IDO1) expression levels correlated inversely with IDO1 promoter methylation levels.

11. The aim of the study was to develop a practical and objective immunohistochemical technique to quantify IDO-1 expression on diagnostic bone marrow biopsies of acute myeloid leukemia patients.

12. IDO activity, expressed as kynurenine/tryptophan ratio, is associated with response to immunotherapy.

13. DNA methylation analysis in humans shows that IDO1 is hypermethylated in human sperm but partially methylated in placentas, suggesting similar methylation patterns to mouse.

14. We conclude that an active hCMV infection in the eye might favor the replication of pathogens causing co-infections in immunosuppressed individuals. An hCMV caused blockade of IDO1 might weaken the eye's immune privilege and favor the development of post-infectious autoimmune uveitis.

15. Expression of PD-L1 and IDO is seen in a subset of high-grade serous ovarian carcinoma from African American women and is correlated with elevated lymphocyte infiltration.

16. Human indoleamine 2,3-dioxygenase 1 (hIDO1) and tryptophan dioxygenase (hTDO) catalyze the same dioxygenation reaction of Trp to generate N-formyl kynurenine (NFK). They share high structural similarity, especially in the active site. However, hIDO1 possesses a unique inhibitory substrate binding site (Si) that is absent in hTDO.

17. Results suggest that indoleamine 23-dioxygenase 1 (IDO1) and programmed cell death-ligand 1 (PD-L1) co-expression may define an aggressive form of lung adenocarcinoma.

18. human cardiac/stem progenitor cells exert an immune-suppressive effect on T lymphocyte proliferation through a paracrine mechanism associated with indoleamine 2,3-dioxygenase (IDO) enzyme-mediated tryptophan metabolism.

19. In summary, IDO and PD-L1 co-expression is common in cervical squamous cell carcinomas and, to a lesser extent, vulvar squamous cell carcinomas.

20. It is a immune checkpoint molecule and modulated during oral epithelial dysplastic changes, and their expression is associated with inflammatory cell infiltration in the lamina propria.

Mouse (Murine) Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaktionspartner

1. Expression of IDO1 in the intestinal epithelial promotes secretory cell differentiation, via Ahr/Notch signaling, and mucus production, to alter muscus-associated bacteria.

2. Ido1 KO mice did not show any clear behavioral abnormalities under normal conditions.

3. IDO1 has a role in an anti-PD1-resistant lung cancer model (344SQ_R) that is different from in the parental 344SQ tumors

4. The current study shows that the Ido1 and Ido2 genes are imprinted and maternally expressed in mouse placentas. DNA methylation analysis demonstrates that nine CpG sites at the Ido1 promoter constitute a differentially methylated region that is highly methylated in sperm but unmethylated in oocytes

5. an unexpected function of indoleamine 2,3-dioxygenase in the fine tuning of intestinal tryptophan metabolism with major consequences on microbiota-dependent control of metabolic disease, is identified.

6. Data show that indoleamine 2,3 dioxygenase-1 (IDO1)/ miR-18a/ killer cell lectin-like receptor subfamily K (NKG2D/NKG2DL) regulatory axis in the regulation of NK cell function.

7. High IDO1 expression is associated with Poststroke Depression.

8. Influenza infection of NIH-3T3 cells elevates the expression of indoleamine 2,3 dioxygenase (IDO). Inhibition against IDO followed by infection increases the level of viral RNA and reduces the upregulation of 3-hydroxyanthranilate 3,4-dioxygenase driven by virus. Induction of IDO appears to contribute to limiting replication of the WSN/33 strain of influenza A virus in murine NIH-3T3 cells.

9. The treatment of Salmonella enterica serovar choleraesuis or resveratrol in murine melanoma cells demonstrated the ability of reducing IDO1 production through upregulating Cx43.

10. Study showed that the knockout of IDO prevented vascular smooth muscle cells apoptosis in AngII -treated Ldlr-/- mice fed with HFD, suggesting a detrimental role of IDO in abdominal aortic aneurysm formation.

11. The KYNurenine pathway of IDO1-mediated Tryptophan metabolism plays a critical role in depressive symptoms associated with IFN-alpha therapy.

12. IDO is a critical regulator of acute pulmonary inflammation .

13. Data suggest that Indoleamine 2,3-dioxygenase 1 (IDO1) appears to be a potential hallmark of liver lesions, and its deficiency protects mice from CCl4-induced fibrosis mediated by Th17 cells down-regulation and tryptophan 2,3-dioxygenase (TDO) compensatory increase.

14. Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment

15. Findings suggest non-redundant neurophysiological roles for indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2 and tryptophan 2,3-dioxygenase in modulating brain activities and metabolism.

16. These results show IDO is upregulated with RSV infection and this upregulation likely participates with IFN-gamma in inhibition of virus replication and suppression of some host cell responses to infection.

17. Lipopolysaccharide (LPS) stimulation increased the expression and activity of the immunoregulatory enzyme IDO1 in hepatic stellate cells (HSCs), and LPS/HSCs stimulated aryl hydrocarbon receptor (AhR) signaling in cocultured regulatory T cells.

18. this study shows that the presence of IFN-alpha at antigen sensitization activates an IDO1/TGF-beta-dependent anti-inflammatory program that upon antigenic rechallenge prevents inflammation via plasmacytoid dendritic cells

19. The deficiency of indoleamine 2,3-dioxygenase aggravates the carbon tetrachloride-induced liver fibrosis in mice.

20. Across strains, networks depicted a predominance of genes under-expressed in microglia relative to macrophages that may be a precursor for the different response of both cell types to challenges. The detected transcriptome differences enhance the understanding of the role of IDO1 in the microglia transcriptome under unchallenged conditions.

Pig (Porcine) Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaktionspartner

1. The results of these studies demonstrate a clear association between rejection and increased allograft IDO expression, likely driven in part by IFN-gamma and facilitated by other cytokines of the allogeneic response.

2. elevated activity and protein expression levels following lipopolysaccharide stimulation