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TDP2 encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. Zusätzlich bieten wir Ihnen TDP2 Antikörper (116) und und viele weitere Produktgruppen zu diesem Protein an.
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Data indicate that tyrosyl-DNA phosphodiesterase 2 (TDP2) alone does not remove DNA topoisomerase II (TOP2 (zeige TOP2 Proteine))-DNA complexes from genomic DNA in vitro and that depletion of TDP2 in cells does not slow the removal of TOP2 (zeige TOP2A Proteine)-DNA complexes.
TDP2 re-localizes from the nucleus to the cytoplasm of EMCV infected cells.
These findings uncover a ZNF451-TDP2-catalyzed and SUMO2 (zeige SUMO2 Proteine)-modulated pathway for direct resolution of TOP2 (zeige TOP2A Proteine) cleavage complex.
TDP2 suppresses chromosome rearrangements induced by TOP2 (zeige TOP2A Proteine) and reduces TOP2 (zeige TOP2A Proteine)-induced chromosome translocations that arise during gene transcription.
Both the genome instability and cell death of MRE11 (zeige MRE11A Proteine)-null and MRE11 (zeige MRE11A Proteine)-mutated H129N cells are significantly reversed by overexpression of Tdp2, an enzyme that eliminates covalent Top2 (zeige TOP2A Proteine) conjugates; thus, the essential role of Mre11 (zeige MRE11A Proteine) nuclease (zeige DCLRE1C Proteine) activity is likely to remove the DNA lesions.
Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 (zeige MAPK4 Proteine) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (zeige TOP2A Proteine) inhibitors.
Data show that DNA-repair enzyme (zeige LIG4 Proteine) TDP2 knockdown in HepG2 cells significantly delays the conversion of relaxed circular DNA (RC-DNA) to covalently closed circular (ccc) DNA.
This article summarizes and compares the biochemistry, functions, and post-translational regulation of TDP1 (zeige TDP1 Proteine) and TDP2, as well as the relevance of TDP1 (zeige TDP1 Proteine) and TDP2 as determinants of response to anticancer agents
Proteolytic degradation of Top2 (zeige TOP2A Proteine) enables the processing of Top2 (zeige TOP2A Proteine).DNA and Top2 (zeige TOP2A Proteine).RNA covalent complexes by TDP2.
TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
EMCV yields are significantly reduced during infection of mouse embryonic fibroblasts genetically ablated for TDP2.
The results collectively provide a structural mechanism for Tdp2 engagement of heterogeneous DNA damage that causes Top2 (zeige TOP2 Proteine) poisoning.
data show that TDP2 activity potentiates enterovirus infections and, in the case of coxsackievirus B3, is a required host function following virus infection of mouse cells
our data reveal TDP2-mediated error-free NHEJ as an efficient and accurate mechanism to repair TOP2 (zeige TOP2 Proteine)-induced DSBs
Evidence implicates Tdp2 in the repair of Top1 (zeige TOP1 Proteine)-mediated DNA damage in cultured cells and in vivo, in the absence of Tdp1 (zeige TDP1 Proteine).
the protein associates with TGF-beta (zeige TGFB1 Proteine) receptors and components of the TRAF6 (zeige TRAF6 Proteine)-TAK1 (zeige NR2C2 Proteine) signaling module
although the role of Smad (zeige SMAD1 Proteine) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad (zeige SMAD1 Proteine) partner that plays an essential role in the fine-tuning of this signal transduction cascade
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
, 5'-tyrosyl-DNA phosphodiesterase
, ETS1-associated protein 2
, ETS1-associated protein II
, TRAF and TNF receptor associated protein
, TRAF and TNF receptor-associated protein
, VPg unlinkase
, tyr-DNA phosphodiesterase 2
, tyrosyl-RNA phosphodiesterase
, TRAF and TNF receptor-associated protein homolog
, Tyr-DNA phosphodiesterase 2
, Traf and Tnf receptor associated protein
, immune transcriptional repressor
, traf and tnf receptor associated protein, like
, tyrosyl-DNA phosphodiesterase 2