serine/threonine Kinase 38 Proteine (STK38)

Human serine/threonine Kinase 38 (STK38) Interaktionspartner

1. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop.

2. Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1.

3. Data show that STK38 supports Ras-driven transformation through promoting detachment-induced autophagy.

4. a novel and intimate link between the protein kinase NDR1 and TGFbeta signaling

5. Data establish STK38 as a conserved regulator of autophagy in human cells and flies.

6. PLK1-mediated phosphorylation protects the binding of Mob1 to NDR1 and subsequent NDR1 activation

7. STK38-mediated phosphorylation of CDC25A at Ser-76 and the subsequent degradation of CDC25A are required to promote DNA damage-induced G2/M checkpoint activation.

8. STK38 regulates MYC protein stability and turnover in a kinase activity-dependent manner. STK38 kinase inactivation abrogates apoptosis following B-cell receptor activation, whereas its silencing significantly decreases MYC levels and increases apoptosis.

9. cyclin D1 has a role in promoting cell cycle progression by enhancing NDR1/2 kinase activity independent of Cdk4

10. 17-allylamino-17-demethoxygeldanamycin down-regulates STK38, modulating radiosensitivity.

11. Findings suggest a function of NDR1, which may regulate NF-kappaB activation by its kinase activity.

12. GSK-3beta inhibits full activation of STK38, and STK38 activation is required to prevent cell death in response to oxidative stress

13. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling.

14. These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells.

15. Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings.

16. NDR1 and NDR2 serine-threonine kinases are regulated by mob proteins

17. an insert within the catalytic domain between subdomains VII and VIII is autoinhibitory, and the binding of human MOB1 to the N-terminal domain of NDR induces the release of this autoinhibition.

18. The NDR1 and NDR2 kinases were incorporated into HIV-1 particles and were cleaved by the HIV-1 protease.

19. In vivo activation of human NDR by membrane-bound hMOBs is dependent on their interaction and occurs solely at the membrane.

20. These data indicate that NDR-driven centrosome duplication requires Cdk2 activity and that Cdk2-induced centrosome amplification is affected upon reduction of NDR activity.

Mouse (Murine) serine/threonine Kinase 38 (STK38) Interaktionspartner

1. These results revealed that Stk38 kinase catalyzes the phosphorylation of Rbm24 during sarcomerogensis and this orchestrates accurate sarcomere alignment.

2. a novel and intimate link between the protein kinase NDR1 and TGFbeta signaling

3. Stk38 protein kinase has a role in inhibiting TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages

4. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling.

5. reduction in the abundances of the NDR proteins NDR1 and NDR2 results in defective responses to proapoptotic stimuli, thereby facilitating the development of tumors