serine Peptidase Inhibitor, Kunitz Type, 2 Proteine (SPINT2)

SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. Zusätzlich bieten wir Ihnen SPINT2 Antikörper (112) und SPINT2 Kits (10) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte SPINT2 SPINT2 292770  
SPINT2 10653 O43291
SPINT2 20733 Q9WU03
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Showing 10 out of 19 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Human Cells Human Fc Tag,ECD 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
$285.35
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Human Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$385.00
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Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
$285.35
Details
Baculovirus infected Insect Cells Human His tag 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$492.31
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Human Cells Human His tag,ECD 50 μg Anmelden zum Anzeigen 14 bis 16 Tage
$634.76
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
Details
Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human SPINT2 Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$653.82
Details

SPINT2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , , , , ,
Mouse (Murine) ,
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Weitere Proteine zu serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) Interaktionspartnern

Human serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) Interaktionspartner

  1. We found only one other report of an optic nerve coloboma associated with SPINT2 mutations and this occurred in a patient with congenital tufting enteropathy. Our patient confirms an association of ocular coloboma with presumed loss of SPINT2 function.

  2. The expression of SPINT2 gene is regulated by its methylation status, and the methylation status of SPINT2 is altered by HPV infection. The aberrant methylation status of SPINT2 gene may play an important role in the development of cervical cancer.

  3. aberrant methylation of the SPINT2 gene is frequently observed in high-grade gliomas and might confer MET signaling in the glioma cells.

  4. finding of only one heterozygous SPINT2 mutation in 19 patients with isolated CA/GA was not statistically significant

  5. In this work, KLK14 binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1) or type-2 (HAI-2) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. KLK14 was successfully modeled.

  6. limited role for HAI-2 in the inhibition of matriptase and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin or matriptase

  7. that the HAI-2 Kunitz domain 1 mutants influence the flux of matriptase to the plasma membrane by affecting the oligomerization, maturation and/or folding of matriptase

  8. Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3.

  9. Concomitant presence of TMPRSS13 with HAI-2 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding.

  10. This study presented a molecular characterization of congenital tufting enteropathy Italian patients, and identified one mutation in the SPINT2 gene

  11. study the methylation status of the promoter region of Serine peptidase inhibitor/hepatocyte growth factor activator inhibitor type 2 (SPINT2/HAI-2)

  12. It suggests an involvement of SPINT2 in PCa tumorigenesis, probably in association with a post-translational regulation of SPINT2.

  13. N-glycan branching regulates HAI-2 through different subcellular distribution and subsequently access to different target proteases

  14. Matriptase inhibition by HAI-2 requires the translocation of HAI-2 to the cell surface, a process which is observed in some breast cancer cells but not in mammary epithelial cells.

  15. Epigenetic silencing of SPINT2 promotes cancer cell motility in malignant melanoma.

  16. a missense mutation in the serine protease inhibitor SPINT2 may have a role in congenital sodium diarrhea

  17. results suggest that the SPINT2 underexpression in the MSC from MDS patients is probably involved in the adhesion of progenitors to the bone marrow niche, through an increased HGF and SDF-1 signaling pathway.

  18. The role of hepatocyte growth factor activator inhibitor-2 (HAI-2) in prostate cancer cell migration, invasion, tumorigenicity and metastasis.

  19. The tumor suppressor gene SPINT2 is commonly silenced by promoter hypermethylation in human esophageal squamous cell carcinoma and SPINT2 hypermethylation is correlated with poor overall survival.

  20. established SPINT2 as a second gene associated with congenital tufting enteropathy

Mouse (Murine) serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) Interaktionspartner

  1. Intestines of HAI-2 deficient mice showed altered expression of epithelial junctional proteins, including reduced levels of EpCAM, E-cadherin, occludin, claudin-1 and -7, as well as an increased level of claudin-4, indicating that the loss of HAI-2 compromises intestinal epithelial barrier function.

  2. HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation.

  3. mutations in Prss8 restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos.

  4. HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.

  5. Unlike HAI-1 and matriptase, HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase

  6. Inhibition of the transmembrane serine protease matriptase (encoded by St14) is an essential function of HAI2 during tissue morphogenesis.

SPINT2 Protein Überblick

Protein Überblick

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SPINT2

  • serine peptidase inhibitor, Kunitz type, 2 (Spint2)
  • serine peptidase inhibitor, Kunitz type 2 (SPINT2)
  • serine protease inhibitor, Kunitz type 2 (Spint2)
  • AL024025 Protein
  • C76321 Protein
  • DIAR3 Protein
  • HAI-2 Protein
  • HAI2 Protein
  • Kop Protein
  • PB Protein

Bezeichner auf Proteinebene für SPINT2

hepatocyte growth factor activator inhibitor type 2 , placental bikunin , serine protease inhibitor, Kunitz type 2 , kunitz-type protease inhibitor 2 , serine protease inhibitor, Kunitz type, 2

GENE ID SPEZIES
292770 Rattus norvegicus
10653 Homo sapiens
20733 Mus musculus
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