serine Peptidase Inhibitor, Kazal Type 1 Proteine (SPINK1)

The protein encoded by SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. Zusätzlich bieten wir Ihnen serine Peptidase Inhibitor, Kazal Type 1 Antikörper (77) und serine Peptidase Inhibitor, Kazal Type 1 Kits (23) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SPINK1 6690 P00995
SPINK1 266602 P09656
SPINK1 20730 P09036
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Top serine Peptidase Inhibitor, Kazal Type 1 Proteine auf antikoerper-online.de

Showing 10 out of 19 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$385.00
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Escherichia coli (E. coli) Human His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$685.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Unkonjugiert Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
$394.90
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Hefe REACT_Opossum His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,035.00
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,038.67
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Hefe Pferd His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,038.67
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,038.67
Details

SPINK1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, ,
Rat (Rattus)

Mouse (Murine)

Weitere Proteine zu serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) Interaktionspartnern

Human serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) Interaktionspartner

  1. Data show that alteration in beta-catenin (zeige CTNNB1 Proteine) expression, a core component of the CDH17/beta-catenin (zeige CTNNB1 Proteine) axis, in tumors affects serine peptidase inhibitor Kazal type 1 (SPINK1) serum levels in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) patients.

  2. Findings indicate that the serine protease inhibitor, Kazal type 1 (SPINK1) p.N34S allele may cause reduced SPINK1 expression.

  3. Having correlated our findings with current knowledge of SPINK1's role in exocrine pancreas pathophysiology, we propose that complete and partial functional losses of the SPINK1 gene are associated with quite distinct phenotypes, the former causing a new pediatric disease entity of severe infantile isolated exocrine pancreatic insufficiency (EPI (zeige TFPI Proteine)) .

  4. results suggest that rs142703147:C>A, which disrupts a PTF1L-binding site within an evolutionarily conserved HNF1A (zeige HNF1A Proteine)-PTF1L cis (zeige CISH Proteine)-regulatory module located upstream of the SPINK1 promoter, contributes to the chronic pancreatitis risk haplotype.

  5. Studied mutations in cationic trypsinogen (PRSS1 (zeige PRSS1 Proteine)) and serine protease inhibitor Kazal type 1 (SPINK1) and their association with alcoholic chronic pancreatitis (ACP (zeige NDUFAB1 Proteine)) and idiopathic chronic pancreatitis.

  6. Studies indicate that serine peptidase inhibitor Kazal type 1 (SPINK1) gene, particularly the N34S mutation, has a genetic association with the development of pancreatitis [Meta-analysis].

  7. association between SPINK1 p.N34S gene variation and chronic pancreatitis [review, meta-analysis]

  8. We present the case of a child with a homozygous mutation N34S in the SPINK1 gene, leading to acute recurrent pancreatitis and ultimately to chronic pancreatitis

  9. Used in silico splicing prediction programs to prioritize SPINK1 intronic variants for further quantitative RT-PCR analysis the non-pathological c.194 + 13T > G variant was predicted by different programs to generate a new & viable donor splice site, the prediction scores being comparable to those for the physiological c.194 + 2T donor splice site & even higher than those for the physiological c.87 + 1G donor splice site.

  10. Gene mutations were present in PRSS1 (zeige PRSS1 Proteine) in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 in 23, CTRC in 3, and CPA1 (zeige CPA1 Proteine) in 5. In the 31 patients with mutations in SPINK1, CTRC, or CPA1 (zeige CPA1 Proteine), 16 (51.6%) had homozygous or heterozygous mutations with other mutations.

Cow (Bovine) serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) Interaktionspartner

  1. Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin.

Mouse (Murine) serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) Interaktionspartner

  1. It is a trypsin-specific inhibitor in the pancreas.

  2. IFN regulatory factor 2 (Irf2 (zeige IRF2 Proteine)) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3

  3. SPINK3 modulates sperm physiology through a downstream reduction of endogenous NO concentration and independently of SPINK3 trypsin inhibitory activity.

  4. uterine-gland-derived SPINK3, as a new paracrine modulator, might play an important role in embryo implantation through its influence on stromal decidualization in mice.

  5. Spink3 may act as a growth factor, leading to cell proliferation and regeneration of tissue structure.

  6. Results suggest that regulation of Prss1 (zeige PRSS1 Proteine) and Spink3 expression is involved in the susceptibility to experimentally induced pancreatitis.

  7. Spink3 trypsin inhibitor is required for normal pancreatic development. Data indicate an important relationship between endogenous pancreatic trypsin and Spink3 and the development of pancreatitis.

  8. SPINK3 mRNA is upregulated in chronic pancreatitis.

  9. Spink3 may play important roles in proliferation and/or differentiation of various cell types during development.

serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.

Genbezeichner und Symbole assoziert mit SPINK1

  • serine peptidase inhibitor, Kazal type 1 (SPINK1)
  • serine peptidase inhibitor, Kazal type 1 (Spink1)
  • p12 Protein
  • PCTT Protein
  • Psti Protein
  • SPINK1 Protein
  • Spink3 Protein
  • TATI Protein
  • TCP Protein

Bezeichner auf Proteinebene für SPINK1

pancreatic secretory trypsin inhibitor , serine protease inhibitor Kazal-type 1 , serine protease inhibitor, Kazal type 1 , tumor-associated trypsin inhibitor , PSTI-II , calcium transport inhibitor , caltrin , pancreatic secretory trypsin inhibitor II , pancreatic secretory trypsin inhibitor type II (PSTI-II) , serine peptidase inhibitor, Kazal type 3 , serine protease inhibitor Kazal-type 3 , serine protease inhibitor, Kazal type 3 , serine peptidase inhibitor, Kazal type 1 , prostatic secretory glycoprotein

GENE ID SPEZIES
6690 Homo sapiens
266602 Rattus norvegicus
574092 Bos taurus
740785 Pan troglodytes
100622575 Sus scrofa
20730 Mus musculus
608433 Canis lupus familiaris
101115618 Ovis aries
103347911 Oryctolagus cuniculus
100630883 Equus caballus
708951 Macaca mulatta
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