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GABRG2 encodes a gamma-aminobutyric acid (GABA) receptor. Zusätzlich bieten wir Ihnen GABRG2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 116 products:
Human Polyclonal GABRG2 Primary Antibody für IHC, WB - ABIN152532
Joshi, Sun, Kapur: A mouse monoclonal antibody against the γ2 subunit of GABAA receptors. in Hybridoma (2005) 2011
Show all 8 Pubmed References
Human Polyclonal GABRG2 Primary Antibody für ICC, IF - ABIN152497
Borghese, Werner, Topf, Baron, Henderson, Boehm, Blednov, Saad, Dai, Pearce, Harris, Homanics, Harrison: An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. in The Journal of pharmacology and experimental therapeutics 2006
Show all 6 Pubmed References
Rat (Rattus) Polyclonal GABRG2 Primary Antibody für WB - ABIN361439
Gomez, Froemke, Burden: Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. in eLife 2014
Show all 9 Pubmed References
Human Monoclonal GABRG2 Primary Antibody für ICC, IP - ABIN2690511
Kerti-Szigeti, Nusser: Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells. in eLife 2016
The aim of this case-control study is to investigate whether GABRG2 polymorphisms contribute to susceptibility for Febrile seizure and epilepsy in pooled data of three cohorts, from Malaysia (composed of Malay, Chinese, and Indian), Hong Kong, and Korea.
Study utilized targeted next-gen (zeige GEN1 Antikörper) sequencing to identify a novel splicing variation (NM_198903.2:c.1249-1G > T) in the GABRG2 gene of a febrile seizure (FS) patient. The potential association of ten selected genetic polymorphisms in IL1RN (zeige IL1RN Antikörper) (86-bp VNTR), IL10 (zeige IL10 Antikörper) (rs1900872), PTGS2 (zeige PTGS2 Antikörper) (8 SNPs, rs689465, rs689466, rs20417, rs13306038, rs201931599, rs689470, rs4648306 and rs4648308) with FS was also examined.
This study identified a missense de novo mutation in the GABAA (zeige GABRg1 Antikörper) receptor gamma2 subunit, P302L, in a patient with Dravet syndrome. The mutation has a novel pathogenic mechanism to cause defects in the conductance and gating of GABAA (zeige GABRg1 Antikörper) receptors, which results in hyperexcitability and contributes to the pathogenesis of the genetic epilepsy Dravet syndrome.
This study demonstrated that rescue of PTZ seizure threshold and thalamocortical oscillations in a Gabrg2+/Q390X KI mouse model of Dravet syndrome/GEFS+ by overexpression of wild-type gamma2HA subunits.
Defects in GABRG2/GABAergic neurotransmission participate in the pathogenesis of genetic epilepsies including epileptic encephalopathies.
This review suggest that the pathogenesis of GABRG2 mutations is likely to be due to a combination of reduction of channel function and disturbance of cellular homeostasis due to the presence of mutant protein.
Nova1 (zeige NOVA1 Antikörper) interacts with GABAARgamma2 not only in the central nervous system but also in hepatocellular carcinoma. Nova1 (zeige NOVA1 Antikörper)'s potential mechanism as an oncogene (zeige RAB1A Antikörper) may due to its interaction with GABAA (zeige GABRg1 Antikörper) Rgamma2.
Thus, the presence of active GABA-A receptors, associated with phenotype determination via Ca(2 (zeige CA2 Antikörper)+)-signalling was demonstrated in differentiating human DA neurons.
common variants of GABRG2, RELN (zeige RELN Antikörper) and NRG3 (zeige NRG3 Antikörper) and the GABRG2-RELN (zeige RELN Antikörper)-PTCH1 (zeige PTCH1 Antikörper) interaction networks might confer altered susceptibility to Hirschsprung disease.
GABRG2, in combination with GABRA4 (zeige GABRA4 Antikörper), is associated with autism spectrum disorder in an Argentine dataset.
The results of this study suggesting that mutations like GABRG2(Q390X) may alter brain thermal regulation and precipitate seizures during temperature elevations.
GABAA (zeige GABRg1 Antikörper) receptor (GABAAR) and the Na(+)-K(+)-2Cl(-) cotransporter (zeige SLC12A1 Antikörper) (NKCC1 (zeige SLC12A2 Antikörper)), but not the K(+)-Cl(-) cotransporter (zeige SLC12A4 Antikörper) (KCC2 (zeige SLC12A5 Antikörper)), were expressed in the terminals of the CRH (zeige CRH Antikörper) neurons at the median eminence (ME). In contrast, CRH (zeige CRH Antikörper) neuronal somata were enriched with KCC2 (zeige SLC12A5 Antikörper) but not with NKCC1 (zeige SLC12A2 Antikörper).
This study demonstrated that the reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA (zeige GABRg1 Antikörper) gamma2 R43Q mouse model of absence epilepsy.
Heterozygous Gabrg2(+/Q390X) KI mice are associated with a severe epileptic encephalopathy due to a dominant negative effect of the mutation, while heterozygous Gabrg2(+/-) KO mice are associated with mild absence epilepsy due to simple haploinsufficiency.
This investigation demonstrates striking interfacial GABAA (zeige GABRg1 Antikörper) receptor subunit selectivity in the native milieu, suggesting that asymmetric occupancy of heteropentameric ion channels by alkylphenol-based anesthetics is sufficient to induce modulation of activity.
Study shows that the down-regulation of the gamma2 subunit of postsynaptic GABAARs in NG2 (zeige Vcan Antikörper) cells that accompanies the postnatal switch from synaptic to extrasynaptic GABAergic transmission between interneurons and these cells in the barrel cortex
Dendritic spine abnormalities of Gabrg2+/- mice suggest association of functional defects in glutamatergic transmission with the established anxious-depressive phenotype of these mice
KIF21B (zeige KIF21B Antikörper) participates in the delivery of GABAAR transport vesicles into dendrites.
The study demonstrates the molecular and functional diversity of the GABAAR system within the mouse colon providing a framework for developing GABAAR-based therapeutics in GI disorders.
these findings suggest that gephyrin (zeige GPHN Antikörper) may be a key factor in BDNF (zeige BDNF Antikörper)-dependent GABAAR regulation in the amygdala.
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.
gamma-aminobutyric acid A receptor, gamma 1
, GABA(A) receptor subunit gamma-2
, gamma-aminobutyric acid receptor subunit gamma-2
, gamma-aminobutyric acid A receptor gamma 2
, gamma-aminobutyric acid (GABA) A receptor, gamma 2
, gamma-aminobutyric acid receptor subunit gamma-2-like
, gamma-aminobutyric acid A receptor, gamma 2
, gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2
, gamma-aminobutyric acid A receptor, gamma 2
, GABA-A receptor gamma-2 subunit
, GABA(A) receptor, gamma 2