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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome.
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the behavior of the flap (zeige ALOX5AP ELISA Kits) tips during simulations is different between BACE1 (zeige BACE ELISA Kits) and BACE2. The BACE1 (zeige BACE ELISA Kits) active site cavity is more spacious as compared to that of BACE2. The analysis of 10S loop and 113S loop showed a similar trend to that of flaps, with the BACE1 (zeige BACE ELISA Kits) loops being more flexible and less stable than those of BACE2
RNA-seq evidence of biallelic expression of BACE2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BACE2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals.
Studies suggest that beta-Secretases BACE1 (zeige BACE ELISA Kits)/2 plays an important role in retinal homeostasis and that BACE (zeige BACE ELISA Kits) upregulation in response to stress is a protective measure.
Data suggest that the amino acid residues would be essential for selectivity of beta-amyloid precursor protein cleavage enzymes BACE1 (zeige BACE ELISA Kits) and BACE2 functions and could be sites for the design of selective inhibitors targeting either BACE1 (zeige BACE ELISA Kits) or BACE2.
Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2.
BACE2 cle (zeige BACE ELISA Kits)aves the integral membrane form (zeige PMEL ELISA Kits) of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for (zeige BACE ELISA Kits) the formation of amyloid fibrils and downstream melanosome morphogenesis.
Inhibiting Chrna7 (zeige CHRNA7 ELISA Kits) expression markedly stimulated the production of Abeta (zeige APP ELISA Kits) through the mechanism of increased expression of BACE1 (zeige BACE ELISA Kits) and inhibited expression of BACE2 in SH-SY5Y cells.
BACE2 overexpression in cultured cells was found to lower net amyloid ss-protein levels.
The BACE2 distal promoter contains an activating cis-regulatory element that is responsive to Trichostatin A (TSA (zeige PRDX2 ELISA Kits)) treatment according to promoter reporter assays in HEK (zeige EPHA3 ELISA Kits) 293 cells.
All these data point to a role for BACE2 in the IRbeta trafficking and insulin (zeige INS ELISA Kits) signaling. In conclusion, BACE2 is hereby presented as an important enzyme in beta-cell function.
The absence of BACE2 ameliorates glucose tolerance defects induced by IAPP (zeige IAPP ELISA Kits) overexpression in the beta-cell and promotes beta-cell survival.
the BACE1 (zeige BACE ELISA Kits) homologue BACE2 processes PMEL (zeige PMEL ELISA Kits) to generate functional amyloids. BACE2 is highly expressed in pigment cells and Bace2(-/-) but not Bace1 (zeige BACE ELISA Kits)(-/-) mice display coat color defects, implying a specific role for BACE2 during melanogenesis
non-redundant roles of BACE1/2 in ectodomain shedding with BACE1 regulating a broader and BACE2 a more distinct set of beta-cell-enriched substrates including two proteins of the seizure 6 protein family (SEZ6L and SEZ6L2).
Tmem27 (zeige TMEM27 ELISA Kits) dimerization is a dynamic process involving Bace2
Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass.
The TgBACE2-APP (zeige APP ELISA Kits) mice showed deregulation of BACE2 expression levels that were significantly increased with respect to single TgBACE2 mice.
Data show that BACE1 (zeige BACE ELISA Kits) knockout mice display a complex phenotype, and a combined deficiency of BACE2 and BACE1 (zeige BACE ELISA Kits) enhanced the bace1 (zeige BACE ELISA Kits)-/- lethality.
BACE1 (zeige BACE ELISA Kits) and BACE2 may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP (zeige APP ELISA Kits)
The presence of BACE2 in secretory granules of beta cells suggests that it may play a role in diabetes-associated amyloidogenesis.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
56 kDa aspartic-like protease
, Down syndrome region aspartic protease
, aspartyl protease 1
, beta-secretase 2
, beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
, membrane-associated aspartic protease 1
, transmembrane aspartic proteinase Asp1
, asp 1
, beta-site APP cleaving enzyme 2
, beta-site amyloid precursor protein cleaving enzyme 2