Zinc Finger Protein ZIC 1 Proteine (ZIC1)

ZIC1 encodes a member of the ZIC family of C2H2-type zinc finger proteins. Zusätzlich bieten wir Ihnen ZIC1 Antikörper (77) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ZIC1 7545 Q15915
Ratte ZIC1 ZIC1 64618  
Maus ZIC1 ZIC1 22771 P46684
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen 10 bis 12 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

ZIC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,

Weitere Proteine zu Zinc Finger Protein ZIC 1 (ZIC1) Interaktionspartnern

Human Zinc Finger Protein ZIC 1 (ZIC1) Interaktionspartner

  1. down-regulated expression of ZIC1 contributed to the inhibition of cell proliferation, and inhibited the growth of tumor

  2. our results suggest that the Zic1 promoter methylation rate in plasma-derived DNA is of great significance for the early screening of gastric cancer and monitoring of tumorigenesis

  3. Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.

  4. ZIC1 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.

  5. aberrant methylation is an important mechanism for ZIC1 inactivation in Hepatocellular carcinoma (HCC (zeige FAM126A Proteine)).

  6. ZIC1 is frequently inactivated by promoter hypermethyaltion and functions as a tumor suppressor in thyroid cancer through modulating PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) and MAPK (zeige MAPK1 Proteine) signaling pathways and transcription factor FOXO3a (zeige FOXO3 Proteine).

  7. Loss of ZIC1 expression is associated with malignant pleural mesothelioma.

  8. Methylation of ZIC1, a putative tumor suppressor, may be a novel determinant of ovarian cancer outcome

  9. Zic transcription factors function in patterning hindbrain motor neurons through their regulation of embryonic retinoic acid signaling

  10. Overexpression of ZIC1 results in inactivation of Shh (zeige SHH Proteine), PI(3 (zeige PI3 Proteine))K and MAPK (zeige MAPK1 Proteine) signaling pathways, as well as regulation of multiple downstream targets which are essential for the development and progression of gastric cancer.

Xenopus laevis Zinc Finger Protein ZIC 1 (ZIC1) Interaktionspartner

  1. Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate.

  2. Pax3 (zeige PAX3 Proteine) and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.

  3. Pax3 (zeige PAX3 Proteine) and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.

  4. XMeis3 (zeige MEIS3 Proteine) protein knock down also causes a loss of primary neuron and neural crest cell lineages, without altering expression of Zic, Sox (zeige PIPOX Proteine) or Pax3 (zeige PAX3 Proteine) genes.

  5. Co-activation of Pax3 (zeige PAX3 Proteine) and Zic1, in concert with Wnt (zeige WNT2 Proteine), plays a decisive role for early neural crest determination in the correct place of the Xenopus ectoderm.

  6. These data suggest that interruption of BMP signaling facilitates neural determination via a complex mechanism, involving multiple regulatory factors that cooperate to control zic1 expression

  7. Zic1 directly upregulated the Xfeb gene during early neural development.

  8. Zic1 is an activator of Wnt (zeige WNT2 Proteine) signaling.

  9. Data show that Pax3 (zeige PAX3 Proteine) and Zic1 are necessary and sufficient to promote hatching gland and preplacodal fates, respectively, and that their combined activity is essential to specify the neural crest.

  10. aqp-3b was upregulated by Zic1

Mouse (Murine) Zinc Finger Protein ZIC 1 (ZIC1) Interaktionspartner

  1. Zic1 and Zic2 (zeige ZIC2 Proteine) proteins are essential to control the balance between two defined neuron types in the postnatal forebrain.

  2. Brn2 (zeige POU3F2 Proteine)-Zic1 axis is essential to specify neural fate in retinoic-acid-treated embryonic stem cells.

  3. Zic1 and Zic2 (zeige ZIC2 Proteine) are required for coordinating mature neuronal gene expression patterns.

  4. Association with DNA-bound Pax3 (zeige PAX3 Proteine) strengthens the ability of both Zic1 and Gli2 to transactivate Myf5 (zeige MYF5 Proteine) in the epaxial somite.

  5. Zic1 and Zic4 (zeige ZIC4 Proteine) have both Shh (zeige SHH Proteine)-dependent and -independent roles during cerebellar development and multiple developmental disruptions underlie Zic1/4-related Dandy-walker malformation.

  6. Myf5 (zeige MYF5 Proteine) activation in newly forming somites is delayed in Zic2 (zeige ZIC2 Proteine) mutant embryos until the time of Zic1 activation, and both Zic2 (zeige ZIC2 Proteine) and Myf5 (zeige MYF5 Proteine) require noggin (zeige NOG Proteine) for their activation

  7. Zic1, a neural developmental transcription factor, plays an important role in shear flow mechanotransduction in osteocytes.

  8. findings suggest that Zic1 controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation

  9. The functions of Zic1 and Zic3 (zeige ZIC3 Proteine) may be essential to increasing neural cell numbers regionally in the medial telencephalon and to proper mediolateral patterning of the telencephalon.

  10. This study reveal a new role for Zic1 as a cell-autonomous regulator of key aspects of nucleus formation and axon pathway choice in the ventral brain stem.

ZIC1 Protein Überblick

Protein Überblick

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.

Genbezeichner und Symbole assoziert mit ZIC1

  • Zic family member 1 (ZIC1)
  • Zic family member 1 (Zic1)
  • Zic family member 1 S homeolog (zic1.S)
  • zinc finger protein of the cerebellum 1 (Zic1)
  • opl Protein
  • ZIC Protein
  • ZNF201 Protein

Bezeichner auf Proteinebene für ZIC1

Zic family member 1 (odd-paired homolog, Drosophila) , Zinc finger protein of the cerebellum 1 , zinc finger protein 201 , zinc finger protein ZIC 1 , zic protein member 1 , zinc finger protein of the cerebellum 1 , XZic1 , ZIC-r1 , ZIC-related protein 1 , Zic family member 1 (odd-paired homolog) , Zic-related-1 , xlZic1 , xopl , odd-paired homolog

7545 Homo sapiens
64618 Rattus norvegicus
374103 Gallus gallus
399124 Xenopus laevis
22771 Mus musculus
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