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Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. Zusätzlich bieten wir Ihnen WLS Proteine (5) und und viele weitere Produktgruppen zu diesem Protein an.
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GPR177 as a novel candidate for prognostic marker as well as a promising target for treatment of gastric cancer patients.
Wls is differentially expressed in Intrahepatic Cholangiocarcinoma tissues and positively related to tumor stage and lymphatic invasion.
This study provides a brand new evidence that GOLPH3 (zeige GOLPH3 Antikörper) promotes glioma cell proliferation by facilitating Wls recycling and Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
These data showed that Wls was differentially expressed in HCC (zeige FAM126A Antikörper). Statistical analysis results suggest that Wls expression might increase as HCC (zeige FAM126A Antikörper) progresses.
Wls-SEC12 (zeige PREB Antikörper) binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls that fails to communicate with the COPII machinery cannot effectively support Wnt (zeige WNT2 Antikörper) secretion. These data suggest that formation of early Wnt (zeige WNT2 Antikörper) secretory vesicles is carefully regulated to ensure proper export of functional ligands
we identified novel associations in WLS , ARHGAP1 (zeige ARHGAP1 Antikörper) , and 5' of MEF2C (zeige MEF2C Antikörper) ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD (zeige BEST1 Antikörper) compared to the GWAS SNPs.
Our data suggest that Wls protein is related to tumor metastasis and advanced TNM (zeige ODZ1 Antikörper) stage, and may be used as a new marker for prognosis of gastric carcinoma.
These results indicate that WLS may play a role in invasion and metastasis of colorectal carcinoma.
Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress.
Genetic variation at the WLS and CCDC170 (zeige CCDC170 Antikörper)/ESR1 (zeige ESR1 Antikörper) loci were found to be significantly associated with bone mineral density
WLS role in the principal cells of the caput epididymidis during sperm maturation
Wntless-deficient macrophages presented a unique subset of M2-like macrophages with anti-inflammatory, reparative, and angiogenic properties. Serial echocardiography studies revealed that mice lacking macrophage Wnt (zeige WNT2 Antikörper) secretion showed improved function and less remodeling 30 days after myocardial infarction.
GPR177 in Sertoli cells had no apparent influence on spermatogenesis, whereas loss of GPR177 in germ cells disrupted spermatogenesis in an age-dependent manner.
these results suggest that Gpr177 controls epithelial initiation of the fungiform placode through signaling via epithelial Wnt (zeige WNT2 Antikörper) ligands.
regulates chondrogenesis and osteogenesis through both canonical and noncanonical Wnt (zeige WNT2 Antikörper) signaling
Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than hematopoietic stem cells maintenance.
Wls-mediated secretion of Wnt (zeige WNT2 Antikörper) ligands from the developing ventral body wall mesenchyme plays a critical role in fusion of the sternum and closure of the secondary body wall.
eletion of the Wls gene in odontoblasts appears to reduce canonical Wnt (zeige WNT2 Antikörper) activity, leading to inhibition of odontoblast maturation and root elongation.
The existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1 (zeige ATOH1 Antikörper), and Pax6 (zeige PAX6 Antikörper) in the rhombic lip provides novel views of early cerebellar development.
Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium
the chaperon Wls and its ligands Wnt9a (zeige WNT9A Antikörper) and Wnt5b (zeige WNT5B Antikörper) are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb (zeige FRZB Antikörper) and Gpc4 (zeige GPC4 Antikörper).
disruption of wls resulted in a significant loss of craniofacial bone, whereas lack of gpc4 (zeige GPC4 Antikörper), wnt5b (zeige WNT5B Antikörper) and wnt9a (zeige WNT9A Antikörper) resulted in severely delayed endochondral ossification.
Homozygous wls mutants show a reduction in two cell populations that contribute to the presumptive dorsal habenulae.
The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt (zeige WNT2 Antikörper) secretion in a variety of embryonic and adult tissue types.
The uncharacterized Drosophila protein Evi5 (zeige EVI5 Antikörper) was identified as an essential membrane trafficking regulator, and the molecular mechanism by which Evi5 (zeige EVI5 Antikörper) regulates BC migration was described.
Syx1A, Rab11, and its effector Myosin5 were required for proper Evi vesicle release.
DSNX3 regulates Wg secretion via retromer-dependent Wls recycling
Por-mediated lipidation of the S239-equivalent residue is essential for the interaction with, and secretion by, Wls.
we propose that Wntless represents an ancient partner for Wnts dedicated to promoting their secretion into the extracellular milieu.
The function of Srt is restricted to events occurring within the Wg-producing cells, study shows that srt is not required for any aspect of Hedgehog (Hh) signal transduction, suggesting specificity of srt for the Wg pathway.
Recent studies have identified Wntless (Wls) and the retromer complex as essential components involved in Wnt signaling.
Wg, clathrin-mediated endocytosis and retromer sustain a Wls traffic loop from the Golgi to the plasma membrane and back to the Golgi, thereby enabling Wls to direct Wnt (zeige WNT4 Antikörper) secretion.
WntD, a recently characterized Drosophila Wnt family member, does not require Porcupine or Wntless/Evi/Sprinter for its secretion or signaling activity
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
G protein-coupled receptor 177
, integral membrane protein GPR177
, protein evenness interrupted homolog
, protein wntless homolog
, putative NF-kappa-B-activating protein 373
, putative NFkB activating protein 373
, evenness interrupted