anti-Wntless Homolog (Drosophila) (WLS) Antikörper

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. Zusätzlich bieten wir Ihnen WLS Proteine (5) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
WLS 79971 Q5T9L3
WLS 68151 Q6DID7
WLS 362065 Q6P689
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Top anti-WLS Antikörper auf antikoerper-online.de

Showing 10 out of 19 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB Human Muscle 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-GPR177 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Liver Host:  Rabbit  Target Name:  WLS  Sample Tissue:  Human THP-1 Whole Cell  Antibody Dilution:  1ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$727.83
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
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Hund Kaninchen Unkonjugiert IHC, ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details
Human Kaninchen Unkonjugiert WB GPR177 antibody used at 1 ug/ml to detect target protein. 50 μg Anmelden zum Anzeigen 9 bis 11 Tage
$473.93
Details
Human Kaninchen Unkonjugiert IHC, WB GPR177 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Skeletal muscle cells (arrows) in Human Muscle. Magnification is at 400X GPR177 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X 50 μg Anmelden zum Anzeigen 9 bis 11 Tage
$510.36
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB Immunohistochemistry-Paraffin: GPR177/WLS Antibody  - Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in cytotrophoblastic cells. Immunocytochemistry/Immunofluorescence: GPR177/WLS Antibody  - Staining of human cell line AF22 shows localization to endoplasmic reticulum. 100 μL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Human Huhn Unkonjugiert ICC, IHC, WB Western Blot analysis of WLS polyclonal antibody (1:2000) on HEK293 cell transfected with WLS-GFP. The 293 cell protein lysate contains both transfected WLS-GFP fusion protein (75KDa) and endogenous WLS protein (~55KDa). 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$349.54
Details
Human Huhn Unkonjugiert WB   0.1 mL Anmelden zum Anzeigen 2 bis 3 Tage
$412.50
Details

Weitere Antikörper gegen WLS Interaktionspartner

Human Wntless Homolog (Drosophila) (WLS) Interaktionspartner

  1. GPR177 as a novel candidate for prognostic marker as well as a promising target for treatment of gastric cancer patients.

  2. Wls is differentially expressed in Intrahepatic Cholangiocarcinoma tissues and positively related to tumor stage and lymphatic invasion.

  3. This study provides a brand new evidence that GOLPH3 promotes glioma cell proliferation by facilitating Wls recycling and Wnt/beta-catenin signaling.

  4. These data showed that Wls was differentially expressed in HCC. Statistical analysis results suggest that Wls expression might increase as HCC progresses.

  5. Wls-SEC12 binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls that fails to communicate with the COPII machinery cannot effectively support Wnt secretion. These data suggest that formation of early Wnt secretory vesicles is carefully regulated to ensure proper export of functional ligands

  6. we identified novel associations in WLS , ARHGAP1 , and 5' of MEF2C ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD compared to the GWAS SNPs.

  7. Our data suggest that Wls protein is related to tumor metastasis and advanced TNM stage, and may be used as a new marker for prognosis of gastric carcinoma.

  8. These results indicate that WLS may play a role in invasion and metastasis of colorectal carcinoma.

  9. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress.

  10. Genetic variation at the WLS and CCDC170/ESR1 loci were found to be significantly associated with bone mineral density

  11. This study has revealed a strong association between the expression of WLS and HER2 that has important biological and clinical implications.

  12. This study identified CMTM8 as a new candidate tumor suppressor gene and GPR177 as a new candidate oncogene in osteosarcoma.

  13. GPR177 played an essential role in disease relapse and poor survival in patients with B-cell precursor acute lymphoblastic leukemia.

  14. endogenous WLS binds Wnts in the endoplasmic reticulum, cycles to the plasma membrane, and then returns to the endoplasmic reticulum through the Golgi.

  15. Colorectal tumors express elevated levels of Wnt3 and GPR177.

  16. The data suggest that the common variants of WLS analyzed in this study are not associated with opioid or cocaine addiction.

  17. Evi expression in psoriatic skin biopsies is down-regulated, suggesting that Evi-deficient mice developed skin lesions that resemble human psoriasis.

  18. findings lead to a proposed mechanism by which Gpr177 controls skeletal development through modulation of autocrine and paracrine Wnt signals in a lineage-specific fashion

  19. WLS functions as a negative regulator of melanoma proliferation and spontaneous metastasis by activating WNT/beta-catenin signalling.

  20. The Evi/Wls overexpression is sufficient to promote downstream Wnt signalling.

Zebrafish Wntless Homolog (Drosophila) (WLS) Interaktionspartner

  1. the chaperon Wls and its ligands Wnt9a and Wnt5b are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb and Gpc4.

  2. disruption of wls resulted in a significant loss of craniofacial bone, whereas lack of gpc4, wnt5b and wnt9a resulted in severely delayed endochondral ossification.

  3. Homozygous wls mutants show a reduction in two cell populations that contribute to the presumptive dorsal habenulae.

  4. The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt secretion in a variety of embryonic and adult tissue types.

Fruit Fly (Drosophila melanogaster) Wntless Homolog (Drosophila) (WLS) Interaktionspartner

  1. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress.

  2. The uncharacterized Drosophila protein Evi5 was identified as an essential membrane trafficking regulator, and the molecular mechanism by which Evi5 regulates BC migration was described.

  3. Syx1A, Rab11, and its effector Myosin5 were required for proper Evi vesicle release.

  4. DSNX3 regulates Wg secretion via retromer-dependent Wls recycling

  5. Por-mediated lipidation of the S239-equivalent residue is essential for the interaction with, and secretion by, Wls.

  6. we propose that Wntless represents an ancient partner for Wnts dedicated to promoting their secretion into the extracellular milieu.

  7. The function of Srt is restricted to events occurring within the Wg-producing cells, study shows that srt is not required for any aspect of Hedgehog (Hh) signal transduction, suggesting specificity of srt for the Wg pathway.

  8. Recent studies have identified Wntless (Wls) and the retromer complex as essential components involved in Wnt signaling.

  9. Wg, clathrin-mediated endocytosis and retromer sustain a Wls traffic loop from the Golgi to the plasma membrane and back to the Golgi, thereby enabling Wls to direct Wnt secretion.

  10. WntD, a recently characterized Drosophila Wnt family member, does not require Porcupine or Wntless/Evi/Sprinter for its secretion or signaling activity

  11. These findings uncover a previously unknown cellular mechanism by which a secreted Wnt is transported across synapses by Evi-containing vesicles and reveal trafficking functions of Evi in both the Wnt-producing and the Wnt-receiving cells.

WLS Antigen-Profil

Protein Überblick

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Genbezeichner und Symbole assoziert mit WLS

  • wntless Wnt ligand secretion mediator (WLS) Antikörper
  • wntless homolog (Drosophila) (Wls) Antikörper
  • wntless Wnt ligand secretion mediator (Wls) Antikörper
  • wntless Wnt ligand secretion mediator (wls) Antikörper
  • wntless (wls) Antikörper
  • 5031439A09Rik Antikörper
  • AI173978 Antikörper
  • AI987742 Antikörper
  • C1orf139 Antikörper
  • CG6210 Antikörper
  • Dmel\\CG6210 Antikörper
  • evi Antikörper
  • Evi/Wls Antikörper
  • gpr117 Antikörper
  • gpr177 Antikörper
  • mig-14 Antikörper
  • MRP Antikörper
  • sb:cb610 Antikörper
  • srt Antikörper
  • Wls Antikörper
  • wls/evi Antikörper
  • wu:fb36d04 Antikörper
  • wu:fb44d10 Antikörper
  • wu:fb50c06 Antikörper
  • zgc:64091 Antikörper

Bezeichner auf Proteinebene für WLS

G protein-coupled receptor 177 , integral membrane protein GPR177 , protein evenness interrupted homolog , protein wntless homolog , putative NF-kappa-B-activating protein 373 , putative NFkB activating protein 373 , EVI , CG6210-PA , CG6210-PB , evenness interrupted , sprinter , wls-PA , wls-PB

GENE ID SPEZIES
79971 Homo sapiens
68151 Mus musculus
362065 Rattus norvegicus
406420 Danio rerio
424707 Gallus gallus
528123 Bos taurus
39259 Drosophila melanogaster
611491 Canis lupus familiaris
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