WW Domain Containing Oxidoreductase Proteine (WWOX)

Fruit Fly (Drosophila melanogaster) WW Domain Containing Oxidoreductase (WWOX) Interaktionspartner

1. the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity.

2. Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity.

3. Aberrant WWOX expression contributes to the altered metabolism in cancer.

4. study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX

5. the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX

Cow (Bovine) WW Domain Containing Oxidoreductase (WWOX) Interaktionspartner

1. data show that the chromosomal location of WWOX is conserved between man and 4 major domesticated species. Moreover, the annotation of the bovine gene also suggests a highly conserved genomic arrangement, including number and size of introns

Human WW Domain Containing Oxidoreductase (WWOX) Interaktionspartner

1. level significantly lower in invasive breast carcinoma specimens compared to normal mammary gland tissues

2. The findings emphasize the importance of the sequestration of WWOX by VOPP1 in addition to WWOX loss in breast tumors and define VOPP1 as a novel oncogene promoting breast carcinogenesis by inhibiting the anti-tumoral effect of WWOX.

3. Enforced expression of TMEM207 abrogated the binding of WWOX to HIF-1alpha, increased HIF-1alpha and GLUT-1 expression, even under normoxic conditions, and promoted tumour growth.

4. shed new light on the alterations of BCSCs and pave the way for the discovery of novel and more effective therapies to treat breast cancer by targeting WWOX

5. The evidence for a second functional site of PARTICLE triplex formation at WWOX suggests that PARTICLE may form triplex-mediated interactions at multiple positions in the human genome including remote loci. These findings provide a mechanistic explanation for the ability of lncRNAs to regulate the expression of numerous genes distributed across the genome.

6. Taiwanese women with CG/GG in WWOX SNP rs3764340 are susceptible to cervical invasive cancer.

7. The results suggested that WWOX may be involved in invasive cervical squamous cell carcinoma carcinogenesis, and this marker was associated with tumor angiogenesis

8. We have identified a variant in WWOX and in lncRNA RP11-679B19.1 as a diseasemodifying genetic variant associated with recurrent fibrostenotic CD

9. A model is supported in which FRA16D common fragile sites are sequences that may initiate replication in early-mid S phase but are slow to complete replication, and the chromosomal breaks and gaps observed in metaphase cells result from unreplicated DNA.

10. Data conclude that WWOX sensitises EOC to paclitaxel via ER stress-induced apoptosis, and predicts clinical outcome in patients. Thus, ER stress response mechanisms could be targeted to overcome chemoresistance in cancer.

11. Data show that patients with advanced-stage oral cancer were associated with a higher frequency of WWOX rs11545028 polymorphisms with the variant genotype TT than did patients with the wild-type gene.

12. WWOX expression was strongly inhibited in human lung cancers and lung cancer cell lines. Reintroducing WWOX into lung cancer cells inhibited their invasive phenotype through downregulating RUNX2 and its target genes including MMP-9 expression.

13. Our data suggests that the deletion genotypes of CNV-67048 in WWOX predispose their carriers to intracranial aneurysms

14. It has been proposed that Fhit and Wwox loss work synergistically in cancer progression and that DNA damage caused by Fhit could be targeted early in cancer initiation for prevention, while DNA damage caused by Wwox loss could be targeted later in cancer progression, particularly in cancers that develop resistance to genotoxic therapies. (Review)

15. genetic variations in WWOX may be a significant predictor of early HCC occurrence and a reliable biomarker for disease progression

16. a WWOX-p53 network regulates normal bone formation and that disruption of this network in osteoprogenitors results in accelerated osteosarcoma.

17. Low WWOX expression is associated with Head and Neck Squamous Cell Carcinoma.

18. Knockdown of lung WWOX expression in mice was observed to cause neutrophil influx and was accompanied by a corresponding vascular leak and inflammatory cytokine production. In cultured human alveolar epithelial cells, loss of WWOX expression resulted in increased c-Jun- and IL-8-dependent neutrophil chemotaxis toward cell monolayers.

19. a portion of ERK and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 and CD8 expression in MOLT-4.

20. Brca1-Wwox interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox-sufficient cells

Mouse (Murine) WW Domain Containing Oxidoreductase (WWOX) Interaktionspartner

1. Knockdown of lung WWOX expression in mice was observed to cause neutrophil influx and was accompanied by a corresponding vascular leak and inflammatory cytokine production. In cultured human alveolar epithelial cells, loss of WWOX expression resulted in increased c-Jun- and IL-8-dependent neutrophil chemotaxis toward cell monolayers.

2. Brca1-Wwox interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox-sufficient cells

3. Both Wwox null and Wwoxhep-/- mice demonstrated reductions in ApoA-I and Abca1 levels, critical components in reverse cholesterol transport and generation of nascent HDL particles.

4. Aberrant WWOX expression contributes to the altered metabolism in cancer.

5. WWOX plays a critical role in normal central nervous system development and disease.

6. WWOX has many functions, and its deletion affects cellular metabolism and neoplastic progression.

7. Wwox-deficient mice develop normally but succumb to a lethal hypoglycemia early in life. WWOX as a tumor suppressor with emerging role in regulation of aerobic glycolysis.

8. These findings identify a novel role for the tumor suppressor WWOX and show that loss of WWOX expression may drive genomic instability

9. Modeling WWOX inactivation revealed a complex phenotype including postnatal lethality, defects in bone metabolism and steroidogenesis and tumor suppressor function resulting in osteosarcomas.

10. WWOX ablation leads to impaired mammary ductal growth. Moreover, targeted deletion of WWOX is associated with increased levels of fibronectin, a component of the extracellular matrix.

11. the WWOX tumor suppressor gene has in preventing tumorigenesis in breast cancer

12. analysis of the effect of the Wwox tumor suppressor gene in a knockout model

13. analysis of WWOX genomics, partners, and functions [review]

14. The intron/exon boundaries of Wox1 have been identified; the genomic organization has been found to be almost identical to that of human WWOX.

15. phosphorylation of JNK1 and WOX1 is necessary for their physical interaction and functional antagonism

16. WW domain-containing oxidoreductase downregulation induces Tau phosphorylation in vitro

17. sex steroid hormone-induced activation of WOX1 and WOX2 is independent of estrogen receptor and androgen receptor

18. Activated WOX1 is likely to exert apoptosis of neuronal cells in the outer retina during the light-induced injury and in mice with an inherited retinal defect.

19. UV-induced alterations of the FHIT and WWOX fragile site gene expression are involved at least partially in the checkpoint function of DNA damage

20. WOX1 plays a critical role in conferring cellular sensitivity to apoptotic stress and Tyr33 phosphorylation in WOX1 is essential for binding and stabilizing Ser46-phosphorylated p53